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Paper Information

Journal:   OFOGH-E-DANESH   SUMMER 2016 , Volume 22 , Number 3 ; Page(s) 171 To 176.
 
Paper: 

COMPARISON OF HEMODYNAMIC VARIATIONS, BISPECTRAL INDEX AND MYOCLONUS SCORE OF PROPOFOL DOSAGE IN ANESTHESIA INDUCED PATIENTS

 
DOI: 

10.18869/acadpub.hms.22.3.171

 
Author(s):  SHABANIAN GH., RAFIE M., HEIDARI SOURESHJANI S., SHABANIAN A.R., SHABANIAN M.R.*
 
* MEDICINE DEPARTMENT, MEDICINE FACULTY, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Aims: Propofol is the most widely used intravenous anesthetic medication. It is necessary to assess the doses of the medication to determine proper anesthetic depth and to prevent its side-effects. The aim of this study was to compare 1 and 2.5mg/Kg doses of propofol in hemodynamic changes, myoclonus degree, and bi-spectral index (BIS) monitoring level in patients under anesthetic induction.
Materials & Methods: In the two-blind random clinical trial study, 92 patients being candidate for surgery wit general anesthesia induction were studied in Shahr-e Kord Kashani Center in 2013. The subjects, selected via simple sampling method, were randomly divided into two groups. The first and the second groups were received 1 and 2.5mg/kg doses of propofol, respectively. Hemodynamic, myoclonus, and BIS indices were measured at four different times in the groups. Data was analyzed by SPSS 17 using independent T and Chi-square tests, as well as repeated ANOVA and Fisher’s test.
Findings: There was no significant difference between the groups in the hemodynamic variables such as systolic and diastolic blood pressure, mean arterial blood pressure, pulse rate, and BIS (p>0.05). In addition, the change rates of the variables were the same. Nevertheless, there was a significant difference between the groups in the pulse change rate (p=0.032). There was no significant difference between the groups in myoclonus (p>0.05).
Conclusion: The hemodynamic changes and the changes in myoclonus degree and BIS are the same in 1 and 2.5mg/kg doses of propofol in the patients undergoing anesthetic induction.

 
Keyword(s): HEMODYNAMICS, PROPOFOL, BI-SPECTRAL INDEX MONITORING, ANESTHESIA
 
References: 
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