Spirituality plays a major role in providing and improving the mental health and quality of life of the elderly. The present study is carried out with the aim of investigating the effectiveness of spiritual training based on Islamic teachings on quality of life and adjustment ability in the elderly. This research is semi-experimental with a Pretest-Posttest Design with control group. The population of the study includes elderly men living in nursing homes in the city of Ahwaz in 2016, out of which 30 individuals, who scored equal to or above the cutoff point in quality of life and adjustment questionnaires, were selected and randomly divided into two experimental (15 subjects) and control (15 People) groups. The Islamic teachings training program was then conducted for 10 sessions of 30 minutes for the experimental group. During this period, the control group received no intervention. After the end of the program, both groups answered the questionnaires again. Data were analyzed using statistical analysis method of Analysis of Covariance (ANCOVA). The results shows that spiritual training based on Islamic teachings increases the quality of life and adjustment ability in the experimental group. As a result, spirituality therapy can be used as an effective intervention method in improving the quality of life of the elderly and their adjustment ability.