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Paper Information

Journal:   PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)   SPRING 2017 , Volume 15 , Number 1 ; Page(s) 23 To 35.
 
Paper: 

EFFECT OF CATECHIN ON SERUM LEVELS OF INFLAMMATORY CYTOKINES, ANTIOXIDANT ENZYMES ACTIVITY AND DNA OXIDATIVE DAMAGE OF OVARIAN TISSUE IN POLYCYSTIC OVARIAN SYNDROME RAT MODEL

 
DOI: 

10.29252/jmj.15.1.23

 
Author(s):  RAHBARIAN RAHELEH, SADOUGHI SEYED DAMOON*
 
* YOUNG RESEARCHERS AND ELITE CLUB, MASHHAD BRANCH, ISLAMIC AZAD UNIVERSITY, MASHHAD, IRAN
 
Abstract: 

Introduction: Women with polycystic ovary syndrome (PCOS) suffer anovulation due to hormonal disorders, oxidative stress and ovarian tissue inflammation. Catechin is the most important green tea flavonoids (Camellia sinensis) with antioxidant properties. This study aimed to determine the effects of catechin on serum levels of inflammatory cytokines, antioxidant enzymes activity and DNA oxidative damage of ovarian tissue in polycystic ovarian syndrome rat model.
Materials & Methods: In this experimental study, 24 Wistar female rats were divided into 4 equal groups (n=6) of control (saline solution, 24 days, ip), non-treated PCOS (saline solution, 24 days, ip) and PCOS treated with catechin (50 and 100 mg/kg, 24 days, ip). Polycystic ovarian syndrome was induced by single intramuscular injection of estradiol valerate (4 mg/kg). At the end of treatment period, serum levels of TNF-
a, IL-1b, IL-6, SOD, CAT, GPX and levels of MDA and HOdG-8 in ovarian tissue were measured by ELISA.
Results: Compared to non-treated PCOS group, in treated groups with 50 and 100 mg/kg of catechin, serum levels of TNF-
a IL-1b and IL-6 significantly decreased dose-dependently (p<0.05), levels of SOD, CAT, GPX in ovarian tissue significantly increased dose-dependently (p<0.05) and levels of MDA and HOdG-8 significantly decreased dose-dependently (p<0.05).
Conclusion: Catechin decreases serum levels of cytokines, increases activity of antioxidant enzymes, decreases lipid peroxidation and DNA oxidative damage of ovarian tissue in polycystic ovarian syndrome rat model.

 
Keyword(s): POLYCYSTIC OVARIAN SYNDROME, CATECHIN, CYTOKINE, OXIDATIVE STRESS, RAT
 
References: 
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