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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PEDIATRICS   JUNE 2018 , Volume 6 , Number 6 (54); Page(s) 7723 To 7731.
 
Paper: 

EFFECTIVENESS OF GASTROFIX ON DURATION OF DIARRHEA AND LENGTH OF HOSPITALIZATION IN CHILDREN WITH ACUTE GASTROENTERITIS: A RANDOMIZED CONTROLLED TRIAL

 
 
Author(s):  POURROSTAMI KIUMARS, ARJMAND REZA, ASAYESH HAMID, NOROOZI MEHDI, SAFARI OMID*, QORBANI MOSTAFA*
 
* NON-COMMUNICABLE DISEASES RESEARCH CENTER, ALBORZ UNIVERSITY OF MEDICAL SCIENCES, KARAJ, IRAN
 
Abstract: 

Background: According to evidence, the main treatment plans for children with gastroenteritis include the use of an oral solution or intravenous infusion for hydration, continued nutrition; zinc supplementation. The aim of this study was to investigate the effectiveness of Gastro-Fix (registered nutritional supplement) versus placebo on length of hospitalization and duration of diarrhea in children with acute gastroenteritis.
Materials and Methods: We conducted a double blind randomized placebo-controlled trial in children with acute gastroenteritis (age between 6 and 120 months). Three hundred eligible patients randomly allocated to one of two parallel groups, Intervention received Gastro-Fix, whereas the placebo group received baby food (cereal based on skimmed milk and wheat without mineral) for a total of 6 days. Gastro-Fix and baby food was administered as a same sachet that could be opened and mixed in water. The primary outcome was length of hospitalization and duration of diarrhea.
Results: The Mean length of hospitalization in Gastro-Fix and placebo was 3.43+0.57 and 4.70+0.59 day respectively (P<0.001). Median duration of diarrhea was 3 days (range: 3-5, IQR: 3–4 days) in the Gastro-Fix group and 5 days (range 3-6, interquartile range [IQR]: 4–5 days) in the placebo group which was statistically significant (P<0.001). The highest efficacy (diarrhea-free percentage of children) of the Gastro-Fix was observed at day 4 (relative risk [RR]: 0.28; 95% confidence interval [CI]: 0.23-0.35), and at day 5 (RR 0.08; 95% CI: 0.03-0.17) after the intervention.
Conclusion: Finding of this study showed that Gastro-Fix can be effective in reducing duration of diarrhea and length of hospitalization in children with diarrhea. This product is suggested to be used in children with acute gastroenteritis.

 
Keyword(s): CHILDREN, DIARRHEA, LENGTH OF HOSPITALIZATION, GASTRO-FIX GASTROENTERITIS
 
 
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APA: Copy

Pourrostami, K., & ARJMAND, R., & ASAYESH, H., & NOROOZI, M., & SAFARI, O., & QORBANI, M. (2018). EFFECTIVENESS OF GASTROFIX ON DURATION OF DIARRHEA AND LENGTH OF HOSPITALIZATION IN CHILDREN WITH ACUTE GASTROENTERITIS: A RANDOMIZED CONTROLLED TRIAL. INTERNATIONAL JOURNAL OF PEDIATRICS, 6(6 (54)), 7723-7731. https://www.sid.ir/en/journal/ViewPaper.aspx?id=573069



Vancouver: Copy

Pourrostami Kiumars, ARJMAND REZA, ASAYESH HAMID, NOROOZI MEHDI, SAFARI OMID, QORBANI MOSTAFA. EFFECTIVENESS OF GASTROFIX ON DURATION OF DIARRHEA AND LENGTH OF HOSPITALIZATION IN CHILDREN WITH ACUTE GASTROENTERITIS: A RANDOMIZED CONTROLLED TRIAL. INTERNATIONAL JOURNAL OF PEDIATRICS. 2018 [cited 2021July27];6(6 (54)):7723-7731. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=573069



IEEE: Copy

Pourrostami, K., ARJMAND, R., ASAYESH, H., NOROOZI, M., SAFARI, O., QORBANI, M., 2018. EFFECTIVENESS OF GASTROFIX ON DURATION OF DIARRHEA AND LENGTH OF HOSPITALIZATION IN CHILDREN WITH ACUTE GASTROENTERITIS: A RANDOMIZED CONTROLLED TRIAL. INTERNATIONAL JOURNAL OF PEDIATRICS, [online] 6(6 (54)), pp.7723-7731. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=573069.



 
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