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Paper Information

Journal:   JOURNAL OF MEDICAL SIGNALS AND SENSORS (JMSS)   JANUARY-MARCH 2018 , Volume 8 , Number 1; Page(s) 46 To 52.
 
Paper: 

CHARACTERIZATION OF SILK/POLY 3-HYDROXYBUTYRATE-CHITOSAN-MULTI-WALLED CARBON NANOTUBE MICRO-NANO SCAFFOLD: A NEW HYBRID SCAFFOLD FOR TISSUE ENGINEERING APPLICATIONS

 
 
Author(s):  MIRMUSAVI MOHAMMAD HOSSEIN, KARBASI SAEED*, SEMNANI DARIUSH, ZARGAR KHARAZI ANOUSHEH
 
* DEPARTMENT OF BIOMATERIALS AND TISSUE ENGINEERING, SCHOOL OF ADVANCED TECHNOLOGIES IN MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Long-term healing tissue engineering scaffolds must hold its full mechanical strength at least for 12 weeks. Nano-micro scaffolds consist of electrospinning nanofibers and textile microfibers to support cell behavior and mechanical strength, respectively.
Methods: The new nano-micro hybrid scaffold was fabricated by electrospinning poly 3-hydroxybutyrate-chitosan-multi-walled carbon nanotube (MWNT functionalized by COOH) solution on knitted silk in a random manner with different amounts of MWNT. The physical, mechanical, and biodegradation properties were assessed through scanning electron microscopy, Fourier-transform infrared (FTIR) spectroscopy, water contact angle test, tensile strength test, and weight loss test. The scaffold without MWNT was chosen as control sample.
Results: An increase in the amount of MWNT up to 1 wt% leads to better fiber diameter distribution, more hydrophilicity, biodegradation rate, and higher tensile strength in comparison with other samples. The porosity percentage of all scaffolds is more than 80%. According to FTIR spectra, the nanofibrous coat on knitted silk did not have any effect on silk fibroin crystallinity structures, and according to tensile strength test, the coat had a significant effect on tensile strength in comparison with pure knitted silk (P?0.05). The average fiber diameter decreased due to an increase in electrical conductivity of the solution and fiber stretch in electrical field due to MWNTs. The scaffold containing 1 wt% MWNT was more hydrophilic due to the presence of many COOH groups of functionalized MWNT, thus an increase in the hydrolysis and degradation rate of this sample.
Conclusions: High intrinsic tensile strength of MWNTs and improvement of nano-micro interface connection lead to an increase in tensile strength in scaffolds containing MWNT.

 
Keyword(s): CARBON NANOTUBE, KNITTED SILK, LONG-TERM HEALING TISSUE ENGINEERING, NANO-MICRO SCAFFOLD
 
References: 
 
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