The ideas of Paul Twitchell and Rajneesh Osho can be compared with each other in several ways. By the comparison of these ideas, we will achieve two similar points and also two different points. The two similar points are: First, both of them held to the same sense of reincarnation and acknowledged the unilateral influence of Karma on the cycle of life; second, both of them acknowledged the importance of proof for reincarnation, relying on “reminding theory” and also their own spiritual experiences. The different aspects are as follows: first, they have two different approaches to reincarnation. It means that Twitchell highlights the reminding theory and holds to the importance of self-knowledge. By emphasizing this principle that "The only way to know yourself is to observe yourself" he pays a special attention to the reminding theory. On the contrary, Osho who gives a particular attention to the pain which comes from the repeated cycles of life believes that the most important thing is freedom from pain and that happiness is the criterion for the relief from pain. Second, Twitchell by drawing an ontological system believes that the way to salvation from reincarnation is to withdraw from the mental worlds and to enter into the spiritual worlds. This kind of enttering and exiting has different consequences, the freedom from reincarnation being the most important among them. On the other hand, Osho believes that the freedom from reincarnation will be achieved only by the realization of Nirvana and the unity with Brahman. In this paper we realize that despite the similarities and differences, reincarnation has a fundamental importance in their thinking.