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Paper Information

Journal:   KNOWLEDGE AND HEALTH   SUMMER 2015 , Volume 10 , Number 2 ; Page(s) 33 To 38.
 
Paper: 

ANTIOXIDANT EFFECTS OF VITAMIN E ON LIVER OXIDATIVE STRESS AFTER RENAL ISCHEMIA REPERFUSION IN MICE

 
 
Author(s):  KHASTAR HOSSEIN, HATAMI LEILI*
 
* DEPT. OF BASIC SCIENCE, SCHOOL OF MEDICINE, SHAHROUD UNIVERSITY OF MEDICAL SCIENCES, SHAHROUD, IRAN
 
Abstract: 

Introduction: Recent studies have reported that remote organs, such as liver are affected by renal ischemia reperfusion. Oxidative stress has been proposed as one of the causative factors of these damages. This study was designed to evaluate the protective effects of vitamin E on the liver oxidative stress after renal ischemia reperfusion (IR).
Methods: Male mice were subjected to three groups (n=9): Sham operated, renal IR (45 min ischemia) and renal IR+Vitamin E (150 mg/kg trough feeding tube for 28 days) after 24 h of reperfusion. Animals were anesthetized and blood samples were obtained from the heart. Moreover, liver tissues were collected for tissue enzyme evaluation.
Results: IR increased plasma concentration of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and also decreased liver tissues superoxide dismutase (SOD) and catalase (CAT). Vitamin E consumption diminished plasma AST and ALT and increased SOD and CAT activity in liver tissues.
Conclusion: These findings showed that vitamin E consumption prevented the IR-induced liver damage and preserved liver tissues antioxidant enzyme after IR-induced oxidative stress.

 
Keyword(s): RENAL ISCHEMIA, REPERFUSION, LIVER DAMAGE, VITAMIN E, OXIDATIVE STRESS
 
 
References: 
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Citations: 
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APA: Copy

KHASTAR, H., & HATAMI, L. (2015). ANTIOXIDANT EFFECTS OF VITAMIN E ON LIVER OXIDATIVE STRESS AFTER RENAL ISCHEMIA REPERFUSION IN MICE. KNOWLEDGE AND HEALTH, 10(2 ), 33-38. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572846



Vancouver: Copy

KHASTAR HOSSEIN, HATAMI LEILI. ANTIOXIDANT EFFECTS OF VITAMIN E ON LIVER OXIDATIVE STRESS AFTER RENAL ISCHEMIA REPERFUSION IN MICE. KNOWLEDGE AND HEALTH. 2015 [cited 2021July31];10(2 ):33-38. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572846



IEEE: Copy

KHASTAR, H., HATAMI, L., 2015. ANTIOXIDANT EFFECTS OF VITAMIN E ON LIVER OXIDATIVE STRESS AFTER RENAL ISCHEMIA REPERFUSION IN MICE. KNOWLEDGE AND HEALTH, [online] 10(2 ), pp.33-38. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572846.



 
 
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