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Paper Information

Journal:   KNOWLEDGE AND HEALTH   SUMMER 2015 , Volume 10 , Number 2 ; Page(s) 47 To 55.
 
Paper: 

SAFFRON EXTRACT DIMINISHES LEARNING DEFICITS IN BRAIN HYPOPERFUSION

 
 
Author(s):  BAGHERIAN ALI, MIRZAEI MOTAHAREH, MIRZAEI HAMED, RAHMATI MAJID*
 
* DEPT. OF BASIC SCIENCES, SCHOOL OF MEDICINE, SHAHROUD UNIVERSITY OF MEDICAL SCIENCES, SHAHROUD, IRAN
 
Abstract: 

Introduction: Current study was conducted because of a social demand to treat and prevent rising cognitive damages following oxidative stress occur due to several reasons including reduced blood supply to the brain following cerebral ischemic lesions and cardiovascular diseases.
Methods: In present study male albino rats were divided into test and control groups. In the test group saffron extract was administered daily for seven days and the other group received normal saline at the same time. Then by performing surgery, in one half of rats in each group, two common carotid arteries were ligated. The ligation reduced blood flow and made lesion in the brain. After surgery, all rats in the test group, were retaken medication for 4 days followed by assessment using behavioral morris water maze task.
Results: Test analysis showed there was a significant difference between treated and control group. Moreover, saffron extract attenuated brain hypoperfusion induced learning disorder.
Conclusion: The results of this study showed that saffron extract treatments decreased rat cognitive defects caused by reduced brain blood flow following appearance of free oxygen radicals and oxidative damage in hippocampus area.

 
Keyword(s): SAFFRON EXTRACT, HYPOPERFUSION, HYPOCAMP, LEARNING, FREE RADICAL
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

BAGHERIAN, A., & Mirzaei, M., & MIRZAEI, H., & RAHMATI, M. (2015). SAFFRON EXTRACT DIMINISHES LEARNING DEFICITS IN BRAIN HYPOPERFUSION. KNOWLEDGE AND HEALTH, 10(2 ), 47-55. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572816



Vancouver: Copy

BAGHERIAN ALI, Mirzaei Motahareh, MIRZAEI HAMED, RAHMATI MAJID. SAFFRON EXTRACT DIMINISHES LEARNING DEFICITS IN BRAIN HYPOPERFUSION. KNOWLEDGE AND HEALTH. 2015 [cited 2021July26];10(2 ):47-55. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572816



IEEE: Copy

BAGHERIAN, A., Mirzaei, M., MIRZAEI, H., RAHMATI, M., 2015. SAFFRON EXTRACT DIMINISHES LEARNING DEFICITS IN BRAIN HYPOPERFUSION. KNOWLEDGE AND HEALTH, [online] 10(2 ), pp.47-55. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572816.



 
 
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