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Paper Information

Journal:   MODARES MECHANICAL ENGINEERING   JULY 2017 , Volume 17 , Number 4 ; Page(s) 307 To 314.
 
Paper: 

NUMERICAL SIMULATION OF MICRO/NANO MAGNETIC PARTICLES MOVEMENT IN BLOODSTREAM CONSIDERING INTERACTION OF PARTICLES

 
 
Author(s):  AMI AHMADI HESAM, BEIGZADEH BORHAN*
 
* SCHOOL OF MECHANICAL ENGINEERING, IRAN UNIVERSITY OF SCIENCE AND TECHNOLOGY, TEHRAN, IRAN
 
Abstract: 

Controlling the path of drugs movement is one of the processes that can effectively aid in treating a variety of diseases. For example, in chemotherapy, a small fraction of a drug is delivered to cancer cells and other amounts can cause destruction of healthy tissues of body, as a result, before destruction of tumors, the body might be destroyed. Hence tumors cannot be removed from the body completely. If it is possible to control the path of drugs, tumors could be removed with the least injury. One of the ways through which movement of the drugs could be controlled is Magnetic Drug Targeting (MDT). In this project, movement of magnetic particles and their interactions would be inspected in the blood with consideration of a constant magnetic field gradient. After introduction of governing equations and presenting a good model for the forces between particles, these processes are be simulated in the Fluent software. The model that is used is a vein with 8 mm diameter. The simulation was done from the time of injection over an 8 cm length of the vein. The base fluid is blood which is considered as a non-Newtonian fluid. Distribution of magnetic particles in the base fluid has been governed by multiphase approach. Simulation results show that residence time of the drug in the presence of magnetic field increases, which in turn increases the possibility of drug absorption.

 
Keyword(s): MAGNETIC DRUG TARGETING, MICRO/NANO MAGNETIC PARTICLES, MULTIPHASE FLOW, BLOOD STREAM
 
References: 
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