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Paper Information

Journal:   ADVANCED JOURNAL OF EMERGENCY MEDICINE   2018 , Volume 2 , Number 1; Page(s) 0 To 0.
 
Paper: 

PAIN RELIEVING EFFECT OF SUBLINGUAL GLYCEROL TRINITRATE IN RENAL COLIC: A RANDOMIZED PLACEBO-CONTROLLED TRIAL

 
 
Author(s):  NASEHI LEYLA, TASLIMI REZA, DEHPOUR AHMADREZA, SEYEDHOSSEINI JAVAD*
 
* DEPARTMENT OF EMERGENCY MEDICINE, SHARIATI HOSPITAL, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Introduction: Renal colic is caused by colicky spasms of ureters. As has been shown in previous experiments, glycerol trinitrate (TNG) can inhibit these muscular spasms.
Objective: This study was performed to assess the pain relieving effect of TNG among patients referred due to renal colic pain to the emergency department (ED).
Methods: This study is a randomized, placebo-controlled study on 60 patients with renal colic who were referred to the ED, who were diagnosed clinically to have renal colic, and their pain was more than 5 based on a visual analogue scale (VAS). The patient's pain was recorded at the moment of clinical diagnosis, and each one received one capsule, either 0.4 mg TNG or placebo, plus a 100 mg indomethacin suppository. The pain score was re-assessed after 5 and 30 min. The values were recorded and compared using SPSS-16 software.
Results: Sixty patients with a mean age of 35.75 ± 11.99 years were enrolled (73.3% male). Patients in the two groups were matched for age (p=0.290), sex (p=0.559), and the presence of microscopic hematuria (p=0.292). Pain relief from the start point until the end of the intervention was statistical different in all studied patients (p<0.05); but the comparison between the two groups showed no significant difference in this regard (p=0.440).
Conclusion: It is likely that adding TNG to an indomethacin suppository had no significant effects on better pain management of patients referred with renal colic to the ED.

 
Keyword(s): EMERGENCY SERVICE, HOSPITAL, NITROGLYCERIN, PAIN MANAGEMENT, RENAL COLIC
 
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