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Paper Information

Journal:   KNOWLEDGE AND HEALTH   SPRING 2015 , Volume 10 , Number 1 ; Page(s) 37 To 43.
 
Paper: 

COMPARISON OF SEROLOGICAL AND BIOPSY DIAGNOSTIC TESTS FOR HELICOBACTER PYLORI IN DYSPEPTIC PATIENTS

 
 
Author(s):  VAHEDI HAMID, SOHRABI MOHAMMAD BAGHER*, ZOLFAGHARI POUNEH, DASHTIPOUR MARJAN, YARMOHAMMADI MARYAM, YAHYAEI ELAHEH, REZA ALI MARYAM, NIKKHESLAT NASIM
 
* IMAM HOSSEIN HOSPITAL, SHAHROUD UNIVERSITY OF MEDICAL SCIENCES, SHAHROUD, IRAN
 
Abstract: 

Introduction: Helicobacter pylori infection is a major cause of chronic gastritis, peptic ulcers and gastric cancer in humans. By using inexpensive laboratory methods for diagnosis of H. pylori infection several complications can be prevented. This study compared two methods including, histology and serology tests for diagnosis of H. pylori in patients with dyspepsia which has been conducted in 2012.
Methods: 395 patients with dyspepsia which referred to Imam Hossein hospital of Shahroud were participated in this study. All patients undergoing endoscopic procedures and 6 standard biopsy specimens were taken for histological examination. Giemsa stain used for histological detection of H. pylori in gastric biopsy specimens serology. H. pylori IgG ELISA method was also performed to measure IgG titers against H. pylori. Data were statistically analyzed and the sensitivity, specificity, positive and negative predictive values were calculated.
Results: From 395 patients with dyspepsia, serological test were positive in 212 patients (53.7%), histological test were positive in 316 (80%) patients including 178 male patients (56.3%) and 138 female patients sensitivity and specificity were 63.9%, and 87.3% respectively. Moreover positive predictive value was 95.3% and negative predictive value was 37.7%.
Conclusion: Due to the high specificity and the relative sensitivity of serological tests as well as simplicity, speed and low cost of these testin comparison with other diagnostic methods these tests could be, recommended for screening.

 
Keyword(s): HELICOBACTER PYLORI, SEROLOGY, BIOPSY, SENSITIVITY, SPECIFICITY
 
References: 
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