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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2018 , Volume 21 , Number 5; Page(s) 525 To 528.
 
Paper: 

GESTATIONAL DIABETES INFLUENCES THE EXPRESSION OF HYPERTROPHIC GENES IN LEFT VENTRICLE OF RAT’S OFFSPRING

 
 
Author(s):  SARAGARD KERMANI ELIA, NAZARI ZAHRA, MEHDIZADEH MEHDI, SHAHBAZI MAJID, GOLALIPOUR MOHAMMAD JAFAR*
 
* GORGAN CONGENITAL MALFORMATIONS RESEARCH CENTER, DEPARTMENT OF ANATOMICAL SCIENCES, GOLESTAN UNIVERSITY OF MEDICAL SCIENCES, GORGAN, IRAN
 
Abstract: 

Objective (s): Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats.
Materials and Methods: Diabetes was induced in 40 adult Wistar rats by intraperitoneal injection of 45 mg/ kg of streptozotocin. The day of appearance of the vaginal plug was assumed as day zero of gestation for inducing diabetes. After pregnancy, the offspring was maintained until they reach the age of 12 weeks. Then, their hearts were excised and were sectioned for molecular study. We analyzed the expression pattern of some hypertrophic genes by the quantitative real-time RT-PCR.
Results: The mRNA expression levels of all studied genes including c-jun, c-fos, c-myc, alpha-myosin heavy chain (
a-MHC), atrial natriuretic factor (ANF) and b-MHC, which are important in cardiomyocyte hypertrophy, were higher in the offspring of the diabetic group compared to controls. Significant differences were found for b-MHC and c-myc with P<0.01 and for a-MHC and c-fos with P<0.05.
Conclusion: Gestational diabetes upregulates expression of c-jun, c-fos c-myc,
a-MHC, ANF and b-MHC genes that are involved in cardiac hypertrophy in the offspring of diabetic rats.

 
Keyword(s): GESTATIONAL DIABETES, HEART, HYPERTROPHIC GENES, OFFSPRING, RATS
 
 
References: 
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APA: Copy

SARAGARD KERMANI, E., & NAZARI, Z., & MEHDIZADEH, M., & SHAHBAZI, M., & GOLALIPOUR, M. (2018). GESTATIONAL DIABETES INFLUENCES THE EXPRESSION OF HYPERTROPHIC GENES IN LEFT VENTRICLE OF RAT’S OFFSPRING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(5), 525-528. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572606



Vancouver: Copy

SARAGARD KERMANI ELIA, NAZARI ZAHRA, MEHDIZADEH MEHDI, SHAHBAZI MAJID, GOLALIPOUR MOHAMMAD JAFAR. GESTATIONAL DIABETES INFLUENCES THE EXPRESSION OF HYPERTROPHIC GENES IN LEFT VENTRICLE OF RAT’S OFFSPRING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2018 [cited 2021July27];21(5):525-528. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572606



IEEE: Copy

SARAGARD KERMANI, E., NAZARI, Z., MEHDIZADEH, M., SHAHBAZI, M., GOLALIPOUR, M., 2018. GESTATIONAL DIABETES INFLUENCES THE EXPRESSION OF HYPERTROPHIC GENES IN LEFT VENTRICLE OF RAT’S OFFSPRING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 21(5), pp.525-528. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572606.



 
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