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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   MARCH 2018 , Volume 16 , Number 3; Page(s) 175 To 182.
 
Paper: 

ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT

 
 
Author(s):  DEPALO RAFFAELLA, TREROTOLI PAOLO, CHINCOLI ANNAROSA*, PATRIZIA VACCA MARGHERITA, LAMANNA GIUSEPPINA, CICINELLI ETTORE
 
* DEPARTMENT OF OBSTETRICS, GYNECOLOGY, NEONATOLOGY AND ANESTHESIOLOGY, UNIT OF MEDICALLY ASSISTED REPRODUCTION AND GAMETES CRYOPRESERVATION, UNIVERSITY HOSPITAL OF BARI CONSORZIALE POLICLINICO, PIAZZA GIULIO CESARE 11.70124 BARI, ITALY
 
Abstract: 

Background: Luteinizing hormone (LH) is essential for normal follicular development and oocyte maturation. In particular, fluctuations of LH during the follicular phase have a significant impact on morphological and functional changes of the oocyte and determine its meiotic status and ability to be fertilized.
Objective: This prospective randomized controlled trial examined effects of endogenous follicular phase LH levels on oocyte maturity and IVF outcomes in fixed vs. flexible in vitro fertilization.
Materials and Methods: Normo-ovulatory women age<39 yr (n=213) were randomized to fixed or flexible gonadotrophin-releasing hormone (GnRH) antagonist protocols. Follicular phase LH, estradiol, and progesterone profiles were measured. Oocytes retrieved, implantation rate, and pregnancy rate were compared between the two groups.
Results: LH profiles were similar in both protocols. A lower trend of LH values at the end of ovarian stimulation correlated significantly with a higher pregnancy rate, regardless of protocol (p=0.02). Estradiol levels were statistically different with respect to time points within treatment groups (p<0.0001), but not between groups (p=0.43), or pregnancy outcomes (p=0.2595). Progesterone profiles were similar between groups. No differences were found in retrieved oocytes numbers, fertilization rate or embryos obtained. Significantly, younger age and a higher number of antral follicles were correlated with positive results.
Conclusion: Fixed and flexible GnRH antagonist protocols did not produce an oscillation of endogenous LH values correlated to the outcome of ovarian stimulation.

 
Keyword(s): IN VITRO FERTILIZATION, LUTEINIZING HORMONE, OVARIAN STIMULATION, OUTCOME
 
 
References: 
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APA: Copy

DEPALO, R., & TREROTOLI, P., & CHINCOLI, A., & PATRIZIA VACCA, M., & LAMANNA, G., & CICINELLI, E. (2018). ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(3), 175-182. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572532



Vancouver: Copy

DEPALO RAFFAELLA, TREROTOLI PAOLO, CHINCOLI ANNAROSA, PATRIZIA VACCA MARGHERITA, LAMANNA GIUSEPPINA, CICINELLI ETTORE. ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2018 [cited 2021July29];16(3):175-182. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572532



IEEE: Copy

DEPALO, R., TREROTOLI, P., CHINCOLI, A., PATRIZIA VACCA, M., LAMANNA, G., CICINELLI, E., 2018. ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 16(3), pp.175-182. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572532.



 
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