Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   MARCH 2018 , Volume 16 , Number 3; Page(s) 149 To 158.
 
Paper: 

THE EFFECT OF RESVERATROL ON OXIDATIVE STRESS IN THE LIVER AND SERUM OF A RAT MODEL OF POLYCYSTIC OVARY SYNDROME: AN EXPERIMENTAL STUDY

 
 
Author(s):  GHOWSI MAHNAZ, KHAZALI HOMAYOUN*, SISAKHTNEZHAD SAJJAD
 
* DEPARTMENT OF ANIMAL PHYSIOLOGY, FACULTY OF BIOLOGICAL SCIENCES AND TECHNOLOGY, SHAHID BEHESHTI UNIVERSITY, TEHRAN,POSTAL CODE: 19839669411, IRAN
 
Abstract: 

Background: Studies of oxidative status in polycystic ovarian syndrome (PCOS) patients are limited with inconsistent results. The effects of resveratrol as a natural antioxidant on oxidative status in PCOS aren’t clear.
Objective: This study evaluated effects of resveratrol on oxidative stress in the liver and serum of the PCOS rats.
Materials and Methods: Fifteen female Wistar rats (3 wk old) were divided into 3 groups (n=5/each e): Control group, PCO-Control group, and PCO-Resveratrol group. For induction of polycystic ovary phenotype, testosterone enanthate 10 mg/kg was injected for 35 days subcutaneously. Then, resveratrol 10 mg/kg was injected intraperitoneally for 28 days to rats of the PCO-Resveratrol group. Ovarian sections were stained with hematoxylin/eosin. The serum glucose and insulin and the levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) in serum and liver were measured.
Results: Control animals showed normal ovarian morphology and PCO-Control animals exhibited cystic follicles. There were no significant differences in liver TAC between groups. The serum MDA (p=0.034), and homeostatic model assessment insulin resistance (HOMA-IR) (p=0.014) levels in PCO-Control rats were higher than the controls. The liver MDA in PCO-Control rats was more than that of controls (p=0.001). The HOMA-IR (p=0.008) and serum MDA (p=0.006) levels in PCO-Control rats were more than those of PCO-Resveratrol rats (p=0.008). In PCOResveratrol group, serum TAC was higher than that of PCO-Control group (p=0.022) and liver MDA was more than controls (p=0.01).
Conclusion: Results indicated that the induction of PCOS in rats increased lipid peroxidation and insulin resistance and resveratrol improved these complications.

 
Keyword(s): OXIDATIVE STRESS, POLYCYSTIC OVARY SYNDROME, RESVERATROL, LIVER
 
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