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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   APRIL 2018 , Volume 21 , Number 4; Page(s) 417 To 421.
 
Paper: 

EFFECT OF MATERNAL FLUOXETINE EXPOSURE ON LUNG, HEART, AND KIDNEY DEVELOPMENT IN RAT NEONATES

 
 
Author(s):  TAGHIZADEH GHAVAMABADI RAZIEH, TAGHIPOUR ZAHRA*, HASSANIPOUR MAHSA, KHADEMI MARZIEH, SHARIATI MEHDI
 
* PHYSIOLOGY-PHARMACOLOGY RESEARCH CENTER, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES, RAFSANJAN, IRAN
 
Abstract: 

Objective (s): Depression during pregnancy negatively affects fetal development. Fluoxetine as a selective serotonin reuptake inhibitor (SSRIs) is used for treatment of gestational depression. This study is trying to determine the effects of fluoxetine on the renal, heart and lung development.
Materials and Methods: Fifteen pregnant rats were treated with fluoxetine at 7 mg/kg from days 0 to 21 of gestation. Immediately after born, heart and kidney samples were evaluated for genes expression and histological assessment. Lung sample were fixed for immunohistochemical study.
Results: The gene expression of BMP7 and WNT4 were reduced in the kidney of fluoxetine-treated group (P -value<0.05), but in the heart of both groups no significant difference was found in gene expression (P -value>0.05). Histological assessment showed that the glomeruli of the kidneys in treated group are more primordial compared to control. There was a developmental deficiency in Bowman’s capsule, and the capsular space was not clear. The arrangements of the filaments, the position of the nucleus and cells morphology were normal in the hearts of both groups. Immunohistochemical analysis demonstrated that in the fluoxetine-exposed group HoxB5 is more expressed in the mesenchymal cells, but in the control group the expression is limited to alveolar cells.
Conclusion: According to developmental changes in kidney, heart and lung, fluoxetine affects neonatal growth during pregnancy, which may lead to delay of some organs growth. So, it is essential to survey the roles of antidepressant drugs on fatal and neonatal development during pregnancy.

 
Keyword(s): FLUOXETINE, HEART, KIDNEY, LUNG, SSRIS
 
 
References: 
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+ Click to Cite.
APA: Copy

TAGHIZADEH GHAVAMABADI, R., & TAGHIPOUR, Z., & HASSANIPOUR, M., & SHARIATI, M., & KHADEMI, M. (2018). EFFECT OF MATERNAL FLUOXETINE EXPOSURE ON LUNG, HEART, AND KIDNEY DEVELOPMENT IN RAT NEONATES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 417-421. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572516



Vancouver: Copy

TAGHIZADEH GHAVAMABADI RAZIEH, TAGHIPOUR ZAHRA, HASSANIPOUR MAHSA, SHARIATI MEHDI, KHADEMI MARZIEH. EFFECT OF MATERNAL FLUOXETINE EXPOSURE ON LUNG, HEART, AND KIDNEY DEVELOPMENT IN RAT NEONATES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2018 [cited 2021August02];21(4):417-421. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572516



IEEE: Copy

TAGHIZADEH GHAVAMABADI, R., TAGHIPOUR, Z., HASSANIPOUR, M., SHARIATI, M., KHADEMI, M., 2018. EFFECT OF MATERNAL FLUOXETINE EXPOSURE ON LUNG, HEART, AND KIDNEY DEVELOPMENT IN RAT NEONATES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 21(4), pp.417-421. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572516.



 
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