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Paper Information

Journal:   JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH   2018 , Volume 10 , Number 1; Page(s) 1 To 13.
 
Paper: 

STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE)

 
 
Author(s):  HASSANPOUR SEYYED HOSSEIN*, DEHGHANI MOHAMMAD AMIN, KARAMI SEYYEDEH ZEINAB
 
* YOUNG RESEARCHERS AND ELITE CLUB, YASOOJ BRANCH, ISLAMIC AZAD UNIVERSITY, YASOOJ, IRAN
 
Abstract: 

The relentlessly beating heart has the greatest oxygen consumption of any organ in the body at rest reflecting its huge metabolic turnover and energetic demands. The vast majority of its energy is produced and cycled in form of ATP which stems mainly from oxidative phosphorylation occurring at the respiratory chain in the mitochondria. A part from energy production, the respiratory chain is also the main source of reactive oxygen species and plays a pivotal role in the regulation of oxidative stress. Dysfunction of the respiratory chain is therefore found in most common heart conditions. The pathophysiology of mitochondrial respiratory chain dysfunction in hereditary cardiac mitochondrial disease, the aging heart, in LV hypertrophy and heart failure, and in ischaemia-reperfusion injury is reviewed. We introduce the practicing clinician to the complex physiology of the respiratory chain, highlight its impact on common cardiac disorders and review translational pharmacological and non-pharmacological treatment strategies.

 
Keyword(s): BEATING HEART, METABOLIC, RESPIRATORY CHAIN, MITOCHONDRIAL, CARDIAC DISORDERS
 
 
References: 
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Citations: 
 
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APA: Copy

HASSANPOUR, S., & DEHGHANI, M., & KARAMI, S. (2018). STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE). JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 10(1), 1-13. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572486



Vancouver: Copy

HASSANPOUR SEYYED HOSSEIN, DEHGHANI MOHAMMAD AMIN, KARAMI SEYYEDEH ZEINAB. STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE). JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH. 2018 [cited 2021July27];10(1):1-13. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572486



IEEE: Copy

HASSANPOUR, S., DEHGHANI, M., KARAMI, S., 2018. STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE). JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, [online] 10(1), pp.1-13. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572486.



 
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