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Paper Information

Journal:   JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2017 , Volume 19 , Number 2 (62) ; Page(s) 59 To 64.
 
Paper: 

DRUG SUSCEPTIBILITY TESTING OF CLINICAL ISOLATES OF CANDIDA ALBICANS AGAINST AMPHOTERICIN B AND KETOCONAZOLE BY MICRODILUTION AND DISK DIFFUSION METHODS

 
 
Author(s):  KAZEMI A., NOWROZI H.*, BADIEE MOGHADAM M.
 
* DEPARTMENT OF LABORATORY SCIENCES, FACULTY OF ALLIED MEDICAL SCIENCES, IRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background and Objective: Candida albicans is the normal flora of the body as opportunistic fungi. It causes candidiasis in immunocompromised condition. This study was done to drug susceptibility testing ofCandida albicans isolated from patients against Amphotericin B and Ketoconazole.
Methods: In this descriptive – analytic study, drug susceptibility of 30 Candida albicans isolated from patients admitted to Tehran hospitals, Iran was tested against Amphotericin B and Ketoconazole by micro dilution method in accordance with CLSI M27-A2 guideline and disk diffusion method in accordance with CLSI M44-S2 guideline. Standard isolateCandida albicans PTCC (5027) and Candida kruseiPTCC (5295) were used for quality control.
Results: The minimum and maximum MIC against Amphotrericin B was 0.0625
mg.ml-1 and 4 mg.ml-1, respectively. The minimum and maximum MIC against Ketoconazole was 0.5 mg/ml-1 and 32 mg/ml-1, respectively. The minimum and maximum zone diameter was 6 and 28 mm for both drugs. The results of drug susceptibility testing by two methods did not show significant differences.
25 isolates (83.3%) against ketoconazole and 2 isolates (6.7%) against Amphotericin B were resistant.
Conclusion: Amphotericin B administration seems better choice in candidiasis treatment in comparision with Ketoconazole.

 
Keyword(s): CANDIDA ALBICANS, AMPHOTERICIN B, KETOCONAZOLE
 
 
References: 
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Citations: 
 
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APA: Copy

KAZEMI, A., & NOWROZI, H., & BADIEE MOGHADAM, M. (2017). DRUG SUSCEPTIBILITY TESTING OF CLINICAL ISOLATES OF CANDIDA ALBICANS AGAINST AMPHOTERICIN B AND KETOCONAZOLE BY MICRODILUTION AND DISK DIFFUSION METHODS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 19(2 (62) ), 59-64. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572481



Vancouver: Copy

KAZEMI A., NOWROZI H., BADIEE MOGHADAM M.. DRUG SUSCEPTIBILITY TESTING OF CLINICAL ISOLATES OF CANDIDA ALBICANS AGAINST AMPHOTERICIN B AND KETOCONAZOLE BY MICRODILUTION AND DISK DIFFUSION METHODS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES. 2017 [cited 2021July29];19(2 (62) ):59-64. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572481



IEEE: Copy

KAZEMI, A., NOWROZI, H., BADIEE MOGHADAM, M., 2017. DRUG SUSCEPTIBILITY TESTING OF CLINICAL ISOLATES OF CANDIDA ALBICANS AGAINST AMPHOTERICIN B AND KETOCONAZOLE BY MICRODILUTION AND DISK DIFFUSION METHODS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, [online] 19(2 (62) ), pp.59-64. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572481.



 
 
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