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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   APRIL 2018 , Volume 21 , Number 4; Page(s) 376 To 381.
 
Paper: 

EVALUATION OF NICOTINIC RECEPTOR OF PEDUNCULOPONTINE TEGMENTAL NUCLEUS IN CENTRAL CARDIOVASCULAR REGULATION IN ANESTHETIZED RAT

 
 
Author(s):  NIKYAR TAHEREH, HOSSEINI MAHMOUD, NIAZMAND SAEED, SHAFEI MOHAMMAD NASER*
 
* NEUROGENIC INFLAMMATION RESEARCH CENTER, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective (s): Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated.
Materials and Methods: Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; doses: 100 and 300 nmol) and higher doses of Hexa (300 nmol) +Ach (150 nmol) microinjected into the PPT. The femoral artery was cannulated and cardiovascular responses were continuously recorded by a power lab system. After injection of drugs, peak changes of mean arterial pressure (
DMAP), systolic blood pressure (DSBP) and heart rate (DHR) calculated and compared with saline group.
Results: The
DSBP and DMAP significantly decreased by two doses of Ach (P<0.05 to P<0.001) but DHR did not change. Two doses 100 (P<0.05) and 300 nmol (P<0.01) of Hexa significantly increased DHR but did not alter the DMAP or DSBP. Co-injection of Hexa+Ach significantly strengthened the DHR induced by Hexa alone (P<0.01) but did not affect DMAP or DSBP.
Conclusion: These results indicate that nicotinic receptor of the PPT has an inhibitory effect on
DHR with no significant effect on DMAP or DSBP.

 
Keyword(s): ACETYLCHOLINE, BLOOD PRESSURE, HEXAMETHONIUM, NICOTINIC RECEPTOR, PEDUNCULOPONTINE TEGMENTAL NUCLEUS
 
 
References: 
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Citations: 
 
+ Click to Cite.
APA: Copy

Nikyar, T., & HOSSEINI, M., & NIAZMAND, S., & SHAFEI, M. (2018). EVALUATION OF NICOTINIC RECEPTOR OF PEDUNCULOPONTINE TEGMENTAL NUCLEUS IN CENTRAL CARDIOVASCULAR REGULATION IN ANESTHETIZED RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 376-381. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572476



Vancouver: Copy

Nikyar Tahereh, HOSSEINI MAHMOUD, NIAZMAND SAEED, SHAFEI MOHAMMAD NASER. EVALUATION OF NICOTINIC RECEPTOR OF PEDUNCULOPONTINE TEGMENTAL NUCLEUS IN CENTRAL CARDIOVASCULAR REGULATION IN ANESTHETIZED RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2018 [cited 2021July26];21(4):376-381. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572476



IEEE: Copy

Nikyar, T., HOSSEINI, M., NIAZMAND, S., SHAFEI, M., 2018. EVALUATION OF NICOTINIC RECEPTOR OF PEDUNCULOPONTINE TEGMENTAL NUCLEUS IN CENTRAL CARDIOVASCULAR REGULATION IN ANESTHETIZED RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 21(4), pp.376-381. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572476.



 
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