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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   APRIL 2018 , Volume 21 , Number 4; Page(s) 370 To 375.
 
Paper: 

DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE

 
 
Author(s):  MOKHTARI HASHTJINI MINA, PIRZAD JAHROMI GILA*, SADR SEYED SHAHABEDDIN, MEFTAHI GHOLAM HOSSEIN, HATEF BOSHRA, JAVIDNAZAR DANIAL
 
* NEUROSCIENCE RESEARCH CENTRE, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Objective (s): Post-traumatic stress disorder (PTSD), one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event followed by intense fear. In rats with contextual fear conditioning (CFC), a model of PTSD caused by CFC (electrical foot shock chamber), deep brain stimulation (DBS) alleviates CFC abnormalities.
Materials and Methods: Forty Male Wistar rats (220–250 g) were divided into 5 groups (n=8) and underwent stereotactic surgery to implant electrodes in the right basolateral nucleus of the amygdala (BLn). After 7 days, some animals received a foot shock, followed by another 7-day treatment schedule (DBS treatment). Next, freezing behavior was measured as a predicted response in the absence of the foot shock (re-exposure time). Blood serum corticosterone levels and amygdala c-Fos protein expression were assessed using Enzymelinked immunosorbent assay (ELISA) and Western blot, respectively. Furthermore, freezing behaviors by re-exposure time test and general anxiety by elevated plus-maze (EPM) were evaluated.
Results: PTSD decreased serum corticosterone levels and increased both amygdala c-Fos expression and freezing behaviors. Therefore, DBS treatment significantly (P<0.001) enhanced serum corticosterone levels and could significantly (P<0.001) reduce both c-Fos protein expression and freezing behaviors’ duration. However, DBS treatment has no effect on the general anxiety in PTSD rats.
Conclusion: We argue that these outcomes might demonstrate the mechanism of DBS treatment, a complete therapeutic strategy, in PTSD patients.

 
Keyword(s): AMYGDALA, ANXIETY BEHAVIOR, CORTICOSTERONE, C-FOS, DEEP BRAIN STIMULATION, FREEZING BEHAVIOR, POST-TRAUMATIC STRESS DISORDER
 
 
References: 
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Citations: 
 
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APA: Copy

MOKHTARI HASHTJINI, M., & Pirzad Jahromi, G., & Sadr, S., & MEFTAHI, G., & Hatef, B., & JAVIDNAZAR, D. (2018). DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 370-375. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572473



Vancouver: Copy

MOKHTARI HASHTJINI MINA, Pirzad Jahromi Gila, Sadr Seyed Shahabeddin, MEFTAHI GHOLAM HOSSEIN, Hatef Boshra, JAVIDNAZAR DANIAL. DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2018 [cited 2021July27];21(4):370-375. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572473



IEEE: Copy

MOKHTARI HASHTJINI, M., Pirzad Jahromi, G., Sadr, S., MEFTAHI, G., Hatef, B., JAVIDNAZAR, D., 2018. DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 21(4), pp.370-375. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572473.



 
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