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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   APRIL 2018 , Volume 21 , Number 4; Page(s) 364 To 369.
 
Paper: 

5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION

 
 
Author(s):  HU BING, FENG XIAOQIAN, WANG LI, SONG YINLI, NI XIUQIN*
 
* DEPARTMENT OF ANATOMY, HARBIN MEDICAL UNIVERSITY DAQING, DAQING, 163319, HEILONGJIANG PROVINCE, CHINA
 
Abstract: 

Objective (s): P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice.
Materials and Methods: Ovalbumin was used to sensitize and challenge for a mouse model. Intranasal application of 5-BDBD, P2X4R antagonist, were performed 3 hr before each airway allergen challenge.
The lung was evaluated for P2X4R by real-time PCR and immunofluorescence. Th1/Th2 cytokines in bronchoalveolar lavage fluid were measured by ELISA. T-bet, Gata-3, and p-p38 MAPK were measured by Western blot or real-time PCR.
Results: P2X4R was overexpressed in the lung after allergen challenge compared with the control group. Blockage of P2X4R decreased inflammation in the lung, IL-4 expression was reduced as well as IL-5; IFN-
g expression was elevated in BALF in ovalbumin-sensitized mice. Moreover, blockage of P2X4R inhibited ovalbumin-induced increased Gata-3 level and decreased T-bet level.
Conclusion: These findings suggest that 5-BDBD ameliorates an ovalbumin-induced asthmatic attack by the downregulation of cytokines related to the Th2 cell.

 
Keyword(s): 5-BDBD, ASTHMA, GATA-3, T-BET, TH2 CELLS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HU, B., & FENG, X., & WANG, L., & SONG, Y., & NI, X. (2018). 5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 364-369. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572465



Vancouver: Copy

HU BING, FENG XIAOQIAN, WANG LI, SONG YINLI, NI XIUQIN. 5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2018 [cited 2021July24];21(4):364-369. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572465



IEEE: Copy

HU, B., FENG, X., WANG, L., SONG, Y., NI, X., 2018. 5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 21(4), pp.364-369. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572465.



 
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