Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   APRIL 2018 , Volume 21 , Number 4; Page(s) 359 To 363.
 
Paper: 

TRANS-CHALCONE ENHANCES INSULIN SENSITIVITY THROUGH THE MIR-34A/SIRT1 PATHWAY

 
Author(s):  KARIMI SALES ELHAM, JEDDI SAJAD, EBRAHIMI KALAN ABBAS, ALIPOUR MOHAMMAD REZA*
 
* DRUG APPLIED RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Objective (s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of trans-chalcone on the miR-34a/SIRT1 pathway as a possible mechanism for its hypoglycemic and hypoinsulinemic effects.
Materials and Methods: In this study, thirty male rats were randomly divided into three groups (n=10): solvent control (NS), oral administration of trans-chalcone for 2 (N2T) and 6 weeks (N6T) groups. Then, hepatic levels of miR-34a and SIRT1 were measured through the qRT-PCR method.
Results: Trans-chalcone reduced food intake, body weight gain, and serum glucose as well as insulin levels.
Also, this chalcone inhibited hepatic miR-34a expression and significantly elevated SIRT1 mRNA level.
Conclusion: Trans-chalcone as an insulin-sensitizing chalcone partly acts through the miR-34a/SIRT1 pathway.

 
Keyword(s): MIR-34A, RAT, SIRT1, TRANS-CHALCONE
 
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