Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2017 , Volume 19 , Number 2 (62) ; Page(s) 1 To 10.
 
Paper: 

ROLE OF VIRUSES IN THE DESTRUCTION OF THE CENTRAL NERVOUS SYSTEM AND ITS IMPACT ON THE MULTIPLE SCLEROSIS

 
 
Author(s):  HASHEMI N., SAEIDI M.*
 
* STEM CELLS RESEARCH CENTER, DEPARTMENT OF IMMUNOLOGY, FACULTY OF MEDICINE, GOLESTAN UNIVERSITY OF MEDICAL SCIENCES, GORGAN, IRAN
 
Abstract: 

Multiple sclerosis (MS) is a chronic inflammatory immune-mediated disease of the central nervous system. Despite extensive investigations, many aspects of etiology and pathophysiology remain unclear. In multiple sclerosis patients, immune system reacts against autologous proteins in the myelin membrane. Most evidences support the hypothesis that both genetic and environmental factors contribute to disease development. But after the failure of genetic findings to explain the reason for the unequal incidence of MS in identical twins, investigators focused further on environmental factors such as vitamin D deficiency, smoking, living in different latitudes and perhaps the most importantly the role of viruses in people whom are genetically susceptible to MS.
There is increasing evidence that viruses may play important role in MS pathogenesis following environmental triggers. Recently, studies focused on the role ofherpes virus family, especially Epstein-Barr virus, human herpes virus 6 (HHV-6) and Varicella Zoster virus, as the virus is prevalent in society.
This review mainly focused on the identification of important viruses with key role in MS the mechanism behind pathogenesis and describes the animal models of MS. The results of researches are shown strong evidence of the virus or antibodies to viral components in active plaques in MS affected patients, but still cannot be stated with certainty that one or more specific viruses are simultaneously trigger the disease. Further studies are required to prove the pathogenesis of viruses in MS.

 
Keyword(s): MULTIPLE SCLEROSIS, ENVIRONMENTAL FACTORS, VIRUS, MYELIN
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

HASHEMI, N., & SAEIDI, M. (2017). ROLE OF VIRUSES IN THE DESTRUCTION OF THE CENTRAL NERVOUS SYSTEM AND ITS IMPACT ON THE MULTIPLE SCLEROSIS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 19(2 (62) ), 1-10. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572459



Vancouver: Copy

HASHEMI N., SAEIDI M.. ROLE OF VIRUSES IN THE DESTRUCTION OF THE CENTRAL NERVOUS SYSTEM AND ITS IMPACT ON THE MULTIPLE SCLEROSIS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES. 2017 [cited 2021July26];19(2 (62) ):1-10. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572459



IEEE: Copy

HASHEMI, N., SAEIDI, M., 2017. ROLE OF VIRUSES IN THE DESTRUCTION OF THE CENTRAL NERVOUS SYSTEM AND ITS IMPACT ON THE MULTIPLE SCLEROSIS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, [online] 19(2 (62) ), pp.1-10. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572459.



 
 
Persian Abstract Yearly Visit 32
 
 
Latest on Blog
Enter SID Blog