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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   JANUARY 2018 , Volume 9 , Number -; Page(s) 0 To 0.
 
Paper: 

THE EFFECTS OF THYMOQUINONE AGAINST MORPHINE?INDUCED DAMAGES ON MALE MICE LIVER

 
 
Author(s):  SALAHSHOOR MOHAMMAD REZA, VAHABI ARMAN, ROSHANKHAH SHIVA, SHABANIZADEH DAREHDORI AHMAD, JALILI CYRUS*
 
* DEPARTMENT OF ANATOMICAL SCIENCES, MEDICAL SCHOOL, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 

Background: Morphine is a pain medication. It is mostly processed in liver and reasons disturbing effects. It can increase the production of free radicals. Thymoquinone is a phytochemical compound found in the plantNigella sativa. It has diverse pharmacological properties such as antioxidant and anticancer. This study was intended to assess the effects of thymoquinone against morphine damages on the liver of mice.
Methods: In this study, various doses of thymoquinone (4.5, 9, and 18 mg/kg) and thymoquinone plus morphine wasadministered (once a day) intraperitoneally to 48 male mice for 20 consequent days. These mice were randomly assigned to eight groups (n=6). Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, serum nitric oxide (NO) levels, liver weight, and histology have been studied.
Results: The results indicated that morphine administration significantly increased the mean diameter of central hepatic vein and hepatocyte, blood serum NO level, liver enzymes level, and decreased liver weight compared to saline group (P<0.05). However, thymoquinone and thymoquinone plus morphine administration significantly enhanced liver weight and reduced the mean diameter of hepatocyte, central hepatic vein, liver enzymes, and NO levels in all groups compared to morphine group (P<0.05).
Conclusions: It seems that antioxidant effect of thymoquinone could protect damage of liver parameters against morphine toxicity.

 
Keyword(s): LIVER, MICE, MORPHINE, THYMOQUINONE
 
 
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+ Click to Cite.
APA: Copy

SALAHSHOOR, M., & VAHABI, A., & ROSHANKHAH, S., & SHABANIZADEH DAREHDORI, A., & JALILI, C. (2018). THE EFFECTS OF THYMOQUINONE AGAINST MORPHINE?INDUCED DAMAGES ON MALE MICE LIVER. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 9(-), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572421



Vancouver: Copy

SALAHSHOOR MOHAMMAD REZA, VAHABI ARMAN, ROSHANKHAH SHIVA, SHABANIZADEH DAREHDORI AHMAD, JALILI CYRUS. THE EFFECTS OF THYMOQUINONE AGAINST MORPHINE?INDUCED DAMAGES ON MALE MICE LIVER. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE. 2018 [cited 2021July25];9(-):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572421



IEEE: Copy

SALAHSHOOR, M., VAHABI, A., ROSHANKHAH, S., SHABANIZADEH DAREHDORI, A., JALILI, C., 2018. THE EFFECTS OF THYMOQUINONE AGAINST MORPHINE?INDUCED DAMAGES ON MALE MICE LIVER. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, [online] 9(-), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572421.



 
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