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Paper Information

Journal:   WORLD JOURNAL OF PLASTIC SURGERY   SEPTEMBER 2016 , Volume 5 , Number 3; Page(s) 274 To 279.
 
Paper: 

FIBROBLAST GROWTH FACTOR-1 VS. FIBROBLAST GROWTH FACTOR-2 IN ISCHEMIC SKIN FLAP SURVIVAL IN A RAT ANIMAL MODEL

 
 
Author(s):  FAYAZZADEH EHSAN*, YAVARIFAR HANA, RAFIE SEYYED REZA, MOTAMED SADROLLAH, SOTOUDEH ANVARI MARYAM, BOROUMAND MOHAMMAD ALI
 
* NO.89, BLOCK B1, SHAHRAK EKBATAN, TEHRAN, POSTAL CODE: 13949-13356, IRAN
 
Abstract: 

BACKGROUND
One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model.
METHODS
Thirty rats were allocated into 3 groups (n=10) and 2
´8 cm dorsal random-pattern skin flaps were raised after four daily subdermal injections of normal saline (control group), fibroblast growth factor 1 (FGF-1 group; 2.5 mg/day), or fibroblast growth factor 2 (FGF-2 group; 2.5 mg/day) at designated flap areas. Skin flap viability and number of blood vessels were evaluated on day 10 after elevation by planimetric analysis and histological examination.
RESULTS
It was shown that administrations of FGF-1 and FGF-2 significantly decreased the percentage of flap necrosis and improved the percentage of ischemic survivable area, compared to the control samples. Meanwhile, the differences between these factors in terms of preventing skin flap necrosis and improving ischemia were also significant. The number of visible blood vessel sections was also higher in FGF-1 and FGF-2 groups than in the control group.
CONCLUSION
These findings suggest that, while FGF-2 is still much more potent than FGF-1, treatment with either of these drugs could be very effective in increasing the survival of surgical flaps at risk (length to width ratio>3) in situations that other therapeutic options could not be considered.

 
Keyword(s): ACIDIC FIBROBLAST GROWTH FACTOR, BASIC FIBROBLAST GROWTH FACTOR, ISCHEMIC NECROSIS, SKIN FLAP SURVIVAL, RAT
 
 
References: 
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Citations: 
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APA: Copy

FAYAZZADEH, E., & YAVARIFAR, H., & RAFIE, S., & MOTAMED, S., & SOTOUDEH ANVARI, M., & BOROUMAND, M. (2016). FIBROBLAST GROWTH FACTOR-1 VS. FIBROBLAST GROWTH FACTOR-2 IN ISCHEMIC SKIN FLAP SURVIVAL IN A RAT ANIMAL MODEL. WORLD JOURNAL OF PLASTIC SURGERY, 5(3), 274-279. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572358



Vancouver: Copy

FAYAZZADEH EHSAN, YAVARIFAR HANA, RAFIE SEYYED REZA, MOTAMED SADROLLAH, SOTOUDEH ANVARI MARYAM, BOROUMAND MOHAMMAD ALI. FIBROBLAST GROWTH FACTOR-1 VS. FIBROBLAST GROWTH FACTOR-2 IN ISCHEMIC SKIN FLAP SURVIVAL IN A RAT ANIMAL MODEL. WORLD JOURNAL OF PLASTIC SURGERY. 2016 [cited 2021August04];5(3):274-279. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572358



IEEE: Copy

FAYAZZADEH, E., YAVARIFAR, H., RAFIE, S., MOTAMED, S., SOTOUDEH ANVARI, M., BOROUMAND, M., 2016. FIBROBLAST GROWTH FACTOR-1 VS. FIBROBLAST GROWTH FACTOR-2 IN ISCHEMIC SKIN FLAP SURVIVAL IN A RAT ANIMAL MODEL. WORLD JOURNAL OF PLASTIC SURGERY, [online] 5(3), pp.274-279. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572358.



 
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