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Paper Information

Journal:   WORLD JOURNAL OF PLASTIC SURGERY   SEPTEMBER 2016 , Volume 5 , Number 3; Page(s) 259 To 264.
 
Paper: 

THE EFFECT OF OLIVERIA DECUMBENS AND PELARGONIUM GRAVEOLENS ON HEALING OF INFECTED SKIN WOUNDS IN MICE

 
 
Author(s):  MAHBOUBI MOHADDESE*, FEIZABADI MOHAMMAD MEHDI, KHAMECHIAN TAHEREH, KAZEMPOUR NASTARAN, RAZAVI ZADEH MOHSEN, SASANI FARHANG, BEKHRADI MOHSEN
 
* MICROBIOLOGY DEPARTMENT, MEDICINAL PLANT RESEARCH CENTER OF BARIJ, KASHAN, IRAN
 
Abstract: 

BACKGROUND
Staphylococcus aureusis one of the most causative organisms in the skin wound infections. Development of resistant S. aureus to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection.
METHODS
The efficacy of herbal formulation containing Oliveria decumbens and Pelargonium graveolens essential oils was evaluated in comparison to mupirocin against Methicillin Resistant S. aureus (MRSA) related skin wound infection in mice animal model.
RESULTS
The herbal cream and mupirocin decreased the log CFU by 2.5
±0.26 and 2.46±0.32, respectively, while the log CFU of S. aureusfrom wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction.
CONCLUSION
This natural new formulation withO. decumbens and P.graveolensessential oils could be recommended as a new candidate for wound healing.

 
Keyword(s): OLIVERIA DECUMBENS, PELARGONIUM GRAVEOLENS, HEALING, INFECTED WOUND, MOUSE
 
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