In surah Yunus, verse 57, the holy Quran is described as shefa’: a healing for the (diseases) in your hearts. Most of Muslim scholars interpreted this healing in a spiritual manner, but in this essay by using different signs, we attempt to demonstrate that content of the verse is general which contain all kinds of healing. Based on discoveries of experimental sciences, most of these signs define mental backgrounds regarding pressure element as the main one of danger in cardiovascular diseases, then elaborate it and explain the way of its healing; as Allah before referring to the characteristic of healing by statement an admonition from your Lord, confirms the possibility of prevention of heart diseases with acting based on Quran’s advices that will be reached by these three elements: Thinking, correct cognition, and believing in Allah. This essay demonstrates that the verse emphasizes on that healing of physical diseases is depended on spiritual one’s healing.