Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   MARCH 2018 , Volume 9 , Number -; Page(s) 0 To 0.
 
Paper: 

ANTIHYPERLIPIDEMIC EFFECT OF DIFFERENT FRACTIONS OBTAINED FROM TEUCRIUM POLIUM HYDROALCOHOLIC EXTRACT IN RATS

 
 
Author(s):  SAFAEIAN LEILA*, GHANADIAN MUSTAFA, SHAFIEE MOGHADAM ZAHRA
 
* DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, ISFAHAN PHARMACEUTICAL SCIENCES RESEARCH CENTER, SCHOOL OF PHARMACY AND PHARMACEUTICAL SCIENCES, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: This study was aimed to screen the antihyperlipidemic effect of different fractions of Teucrium poliumto obtain the most efficient herbal fraction for isolation of bioactive constituents responsible for hypolipidemic activity.
Methods: Chloroform, butanol, and aqueous fractions were obtained from hydroalcoholic extract of T. polium aerial parts using partitioning process. To induce hyperlipidemia, dexamethasone (Dex) was injected 10 mg/kg/day (s.c.) for 8 days. In the test groups, animals received 50, 100 and 150 mg/kg of T. polium hydroalcoholic extract and different fractions orally simultaneously with Dex. Serum lipid profile and hepatic marker enzymes were evaluated using biochemical kits.
Results: All treatments, especially chloroform and aqueous fractions, reversed serum lipid markers in hyperlipidemic rats. Maximum reduction in triglyceride (60.2%, P<0.001) and maximum elevation in high?density lipoprotein (HDL) (35.0%, P<0.01) was observed for chloroform fraction. Maximum cholesterol?lowering effect (29.0%, P<0.001) and maximum reduction in low?density lipoprotein were found for hydroalcoholic extract (72.9%, P<0.001). Aqueous fraction improved all lipid markers at the highest dose. Butanol fraction decreased triglyceride at the lowest dose (43.9%, P<0.001) and increased HDL (33%, P<0.05) at the highest dose. There was a significant increase in alanine aminotransferase and aspartate aminotransferase levels in all tested groups compared to normal group (P<0.001).
Conclusions: This study showed strong antihyperlipidemic effect of various fractions derived from hydroalcoholic extract of T. polium. Chloroform and aqueous fractions may be worthy candidates for isolation of bioactive hypolipidemic constituents. However, possible hepatotoxicity should be considered for clinical application.

 
Keyword(s): DEXAMETHASONE, HEPATOTOXICITY, HYPERLIPIDEMIA, TEUCRIUM POLIUM
 
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