Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   FEBRUARY 2018 , Volume 9 , Number -; Page(s) 0 To 0.
 
Paper: 

ASSOCIATION OF SERUM 25?HYDROXYVITAMIN D LEVELS AND LIVER ENZYMES IN A NATIONALLY REPRESENTATIVE SAMPLE OF IRANIAN ADOLESCENTS: THE CHILDHOOD AND ADOLESCENCE SURVEILLANCE AND PREVENTION OF ADULT NONCOMMUNICABLE DISEASE STUDY

 
 
Author(s):  BAHREYNIAN MARYAM, QORBANI MOSTAFA, MOTLAGH MOHAMMAD ESMAEIL, HESHMAT RAMIN*, KHADEMIAN MAJID*, KELISHADI ROYA
 
* DEPARTMENT OF PEDIATRICS, CHILD GROWTH AND DEVELOPMENT RESEARCH CENTER, RESEARCH INSTITUTE FOR PRIMORDIAL PREVENTION OF NON?COMMUNICABLE DISEASE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Hypovitaminosis D is highly prevalent and has several adverse health effects. This study aims to assess the relationship of serum concentrations of 25?hydroxyvitamin D (25 [OH] D) and liver enzymes in adolescents.
Methods: This population?based cross?sectional survey was conducted among a nationally representative multistage sample of 1095 adolescents (52% boys), aged 10–18 years, living in different provinces of Iran. Serum 25 (OH) D concentration<30 ng/ mL was considered as hypovitaminosis D, and liver enzymes (alanine aminotransaminase [ALT] and aspartate aminotransaminase [AST]) of>40 U/L was considered as high level. To determine the association between serum 25 (OH) D categories and elevated levels of liver enzymes, multiple regression models and linear regression analysis were applied, after adjustment for potential confounders. Odds ratios (95% confidence interval) of serum 25 (OH) D and elevated liver enzymes were assessed by logistic regression analysis.
Results: Higher rates of Vitamin D deficiency were documented among individuals with increased levels of liver enzymes. Compared to boys, median of 25 (OH) D was lower in girls with elevated levels of liver function tests (12.75 vs.25.60 ng/mL for ALT and 13 vs.14.10 ng/mL for AST), with marginally significant gender differences regarding AST.
Conclusions: We found a relatively high frequency of hypovitaminosis D among adolescents with abnormal liver function. Further prospective studies are needed to examine these associations from early life.

 
Keyword(s): ADOLESCENT, LIVER FUNCTION TESTS, VITAMIN D
 
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