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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   FEBRUARY 2018 , Volume 9 , Number -; Page(s) 0 To 0.
 
Paper: 

EFFECTS OF LEVOTHYROXINE ON VISUAL EVOKED POTENTIAL IMPAIRMENT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHIN INTO THE RAT OPTIC CHIASM

 
DOI: 

10.4103/ijpvm.IJPVM_418_16

 
Author(s):  PAYGHANI COBRA, KHANI FATEMEH, RAFIEEZADEH ARYAN, REISI PARHAM*, ALAEI HOJJATALLAH, RASHIDI BAHMAN
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system which has no any known definitive treatment. Studies have shown that thyroid hormones (THs) in addition to their roles in the development of the nervous system and the production of myelin have important roles in the adult’s brain function. Since the only way to treat MS is the restoration of myelin, the aim of this study was to evaluate the effects of levothyroxine on visual evoked potential (VEP) impairment following local injections of lysolecithin into the rat optic chiasm.
Methods: To induce demyelination, lysolecithin was injected into the optic chiasm of male Wistar rats. VEP recording was used to evaluate demyelination and remyelination before and 10, 17, and 24 days after the lysolecithin injection. The rats received an intraperitoneal injection of levothyroxine with doses 20, 50, and 100
mg/kg in different experimental groups.
Results: VEP latency and amplitude showed demyelination at 10 and 17 days after an induced lesion in MS group which was reversed at day 24. Levothyroxine prevented these impairments, especially in high doses.
Conclusions: According to the results, lysolecithin?induced demyelination at optic chiasm and VEP impairments can be restored by administration of levothyroxine. Therefore, THs probably have positive effects in demyelinating diseases.

 
Keyword(s): LEVOTHYROXINE, LYSOLECITHIN, MULTIPLE SCLEROSIS, OPTIC CHIASM, VISUAL EVOKED POTENTIAL
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

PAYGHANI, C., & KHANI, F., & RAFIEEZADEH, A., & REISI, P., & ALAEI, H., & RASHIDI, B. (2018). EFFECTS OF LEVOTHYROXINE ON VISUAL EVOKED POTENTIAL IMPAIRMENT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHIN INTO THE RAT OPTIC CHIASM. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 9(-), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572175



Vancouver: Copy

PAYGHANI COBRA, KHANI FATEMEH, RAFIEEZADEH ARYAN, REISI PARHAM, ALAEI HOJJATALLAH, RASHIDI BAHMAN. EFFECTS OF LEVOTHYROXINE ON VISUAL EVOKED POTENTIAL IMPAIRMENT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHIN INTO THE RAT OPTIC CHIASM. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE. 2018 [cited 2021July26];9(-):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572175



IEEE: Copy

PAYGHANI, C., KHANI, F., RAFIEEZADEH, A., REISI, P., ALAEI, H., RASHIDI, B., 2018. EFFECTS OF LEVOTHYROXINE ON VISUAL EVOKED POTENTIAL IMPAIRMENT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHIN INTO THE RAT OPTIC CHIASM. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, [online] 9(-), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572175.



 
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