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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PEDIATRICS   MARCH 2018 , Volume 6 , Number 3 (51); Page(s) 7345 To 7351.
 
Paper: 

ATRIAL AND VENTRICULAR ELECTROCARDIOGRAPHIC DROMOTROPIC DISTURBANCES IN DOWN SYNDROME PATIENTS WITH STRUCTURALLY NORMAL HEART: A CROSS-SECTIONAL STUDY

 
 
Author(s):  GHANDI YAZDAN, SHARIFI MEHRZAD*, HABIBI DANIAL, ALINEJAD SAEED, ARJMAND ALI, NIKDEL SARA
 
* SARDASHT SQUARE, DEPARTMENT OF CARDIOVASCULAR SURGERY, AMIR-ALMOMENIN EDUCATION AND RESEARCH HOSPITAL, ARAK UNIVERSITY OF MEDICAL SCIENCES, ARAK, IRAN
 
Abstract: 

Background: We designed a cross-sectional study to determine electrocardiographic disorders in Down syndrome patients with congenitally normal hearts in a bid to predict fatal cardiac arrhythmia in the future.
Materials and Methods: We investigated 60 children with DS without congenital abnormal hearts. Sixty healthy juveniles were also included in the study as a control group. Physical examination, electrocardiography, and echocardiography were performed in all subjects. Corrected QT interval (QTc) was measured according to Bazett’s formula.
Results: Patients with DS consisted of 32 males (53.33%), and 28 females (46.66%), aged 6–13 (9.21 ± 6.24) years old. Healthy subjects comprised 31 males (51.66%), and 29 females (48.33%) with a mean age of 9.15 ± 5.01. The two groups were significantly different in terms of heart rate (P=0.006), maximum P-wave duration (P=0.001), and P-wave dispersion (PWd, P=0.0001). There was no statistically significant difference regarding minimum P-wave duration (P=0.176). The patients with DS had a greater maximum QTc interval, QT dispersion, and corrected QT interval dispersion (QTc-d) than the healthy control subjects (P=0.001). However, there was no difference in maximum QT interval and minimum QTc interval between the two groups (P=0.67 and P=0.553, respectively). A positive correlation was found between age, heart rate, and all electrocardiographic variables.
Conclusion: All DS patients, even in the absence of concomitant congenital heart disease should be followed up carefully by electrocardiography, looking for increased PWd and QTc-d to detect predisposed cases to arrhythmia.

 
Keyword(s): CARDIOVASCULAR ABNORMALITIES, CHILDREN, DOWN SYNDROME, CONGENITAL HEART DEFECTS
 
 
References: 
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Citations: 
 
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APA: Copy

GHANDI, Y., & SHARIFI, M., & HABIBI, D., & ALINEJAD, S., & ARJMAND, A., & NIKDEL, S. (2018). ATRIAL AND VENTRICULAR ELECTROCARDIOGRAPHIC DROMOTROPIC DISTURBANCES IN DOWN SYNDROME PATIENTS WITH STRUCTURALLY NORMAL HEART: A CROSS-SECTIONAL STUDY. INTERNATIONAL JOURNAL OF PEDIATRICS, 6(3 (51)), 7345-7351. https://www.sid.ir/en/journal/ViewPaper.aspx?id=572160



Vancouver: Copy

GHANDI YAZDAN, SHARIFI MEHRZAD, HABIBI DANIAL, ALINEJAD SAEED, ARJMAND ALI, NIKDEL SARA. ATRIAL AND VENTRICULAR ELECTROCARDIOGRAPHIC DROMOTROPIC DISTURBANCES IN DOWN SYNDROME PATIENTS WITH STRUCTURALLY NORMAL HEART: A CROSS-SECTIONAL STUDY. INTERNATIONAL JOURNAL OF PEDIATRICS. 2018 [cited 2021August01];6(3 (51)):7345-7351. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572160



IEEE: Copy

GHANDI, Y., SHARIFI, M., HABIBI, D., ALINEJAD, S., ARJMAND, A., NIKDEL, S., 2018. ATRIAL AND VENTRICULAR ELECTROCARDIOGRAPHIC DROMOTROPIC DISTURBANCES IN DOWN SYNDROME PATIENTS WITH STRUCTURALLY NORMAL HEART: A CROSS-SECTIONAL STUDY. INTERNATIONAL JOURNAL OF PEDIATRICS, [online] 6(3 (51)), pp.7345-7351. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=572160.



 
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