Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF DIABETES AND OBESITY   WINTER 2017 , Volume 9 , Number 4; Page(s) 155 To 163.
 
Paper: 

MELIA AZEDARACH L. FRUIT EXTRACT EFFECT ON PLASMA LIPID PROFILE AND CARDIAC AND HEPATIC FUNCTIONS OF DIABETIC RATS

 
 
Author(s):  AFKHAMI ARDEKANI OMID, ESMAILIDEHAJ MANSOUR*, AFKHAMI ARDEKANI MOHAMMAD, ESMAEILI HASSAN, AFKHAMI ARDEKANI AREZOO
 
* DEPARTMENT OF PHYSIOLOGY, FACULTY OF MEDICINE, SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, YAZD, IRAN
 
Abstract: 

Objective: There are controversial reports about biological effects of the Melia Azedarach Linn.
(MA). In the present study, the effect of MA fruit extract on lipid profile, cardiac and hepatic functions of diabetic rats was investigated.
Materials and Methods: Thirty male Wistar rats were divided into five groups. Group 1 as the control group, Group 2 as the diabetic group, Group 3 and 4 as the diabetic rats treated with MA fruit extract (100 and 200 mg/kg for 30 days, orally) and Group 5 as the positive control group treated by Glibenclamide (0.5 mg/kg for 30 days). Diabetes was induced by nicotine amide and streptozotocin.
After 30 days, the plasma concentration of glucose, hemoglobin A1C (HbA1c), lipid profile, hepatic enzymes were measured. Also, electrocardiogram and interventricular pressures were recoded.
Results: The data showed that the plasma levels of glucose, HbA1c, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were significantly increased in the diabetic group. These parameters were higher in groups treated with MA extract, without significant difference. The plasma lipid profile significantly changed in diabetic rats and did not come back to normal level in groups treated with MA extract. Compared to the control group, corrected QT interval was increased and the rate of interventricular pressure changes decreased in all groups. MA extract was as an antioxidant compound against diphenylpicrylhydrazyl (DPPH) free radicals.
Conclusion: These results demonstrated that although MA extract had an antioxidant effect, it did not improve the signs of diabetes in diabetic rats.

 
Keyword(s): MELIA AZEDARACH L., DIABETES, HEART, LIVER, LIPID
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

AFKHAMI ARDEKANI, O., & ESMAILIDEHAJ, M., & AFKHAMI ARDEKANI, M., & Esmaeili, H., & AFKHAMI ARDEKANI, A. (2017). MELIA AZEDARACH L. FRUIT EXTRACT EFFECT ON PLASMA LIPID PROFILE AND CARDIAC AND HEPATIC FUNCTIONS OF DIABETIC RATS. IRANIAN JOURNAL OF DIABETES AND OBESITY, 9(4), 155-163. https://www.sid.ir/en/journal/ViewPaper.aspx?id=571988



Vancouver: Copy

AFKHAMI ARDEKANI OMID, ESMAILIDEHAJ MANSOUR, AFKHAMI ARDEKANI MOHAMMAD, Esmaeili Hassan, AFKHAMI ARDEKANI AREZOO. MELIA AZEDARACH L. FRUIT EXTRACT EFFECT ON PLASMA LIPID PROFILE AND CARDIAC AND HEPATIC FUNCTIONS OF DIABETIC RATS. IRANIAN JOURNAL OF DIABETES AND OBESITY. 2017 [cited 2021July26];9(4):155-163. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=571988



IEEE: Copy

AFKHAMI ARDEKANI, O., ESMAILIDEHAJ, M., AFKHAMI ARDEKANI, M., Esmaeili, H., AFKHAMI ARDEKANI, A., 2017. MELIA AZEDARACH L. FRUIT EXTRACT EFFECT ON PLASMA LIPID PROFILE AND CARDIAC AND HEPATIC FUNCTIONS OF DIABETIC RATS. IRANIAN JOURNAL OF DIABETES AND OBESITY, [online] 9(4), pp.155-163. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=571988.



 
  pdf-File
Yearly Visit 53
 
 
Latest on Blog
Enter SID Blog