Paper Information

Journal:   INTERNATIONAL JOURNAL OF PEDIATRICS   FEBRUARY 2018 , Volume 6 , Number 2 (50); Page(s) 7045 To 7054.
 
Paper: 

ASSOCIATION OF HELICOBACTER PYLORI INFECTION WITH CARDIOMETABOLIC RISK FACTORS AMONG IRANIAN ADOLESCENTS: THE CASPIAN III STUDY

 
 
Author(s):  KALANTAR ENAYATOLLAH, GHARAVI MOHAMMAD JAVAD, GHAFFARI HOSEINI SHERVIN, HESHMAT RAMIN, OSHAGHI MOJGAN, GHAREGOZLOU BEHNAZ, ASAYESH HAMID, MAHDAVI GORABI ARMITA, MOTLAGH MOHAMMAD ESMAEIL, NOROOZI MEHDI, QORBANI MOSTAFA*, KELISHADI ROYA*
 
* DEPARTMENT OF PEDIATRICS, CHILD GROWTH AND DEVELOPMENT RESEARCH CENTER, RESEARCH INSTITUTE FOR PRIMORDIAL PREVENTION OF NON-COMMUNICABLE DISEASE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: At least half the world’s population is colonized the stomach by Helicobacter pylori (H. pylori) which are a key constituent of the human microbiome. The aim of this study was to investigate the association of cardiometabolic risk factors with H. pylori infection in Iranian adolescents. Materials and Methods: The current study was conducted along with the third survey of a national school-based surveillance system in Iran, entitled "Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease" (CASPIAN) study. Detailed questionnaires on demographic, socioeconomic, dietary, and health-related information of the participants were filled by one of the parents under supervision of trained health-care workers. Trained healthcare professionals measured anthropometric indices, blood pressures according to standard protocols. Fasting venous blood was examined for fasting blood sugar and lipid profile.
Results: Overall 882 serum samples were suitable for testing. H. pylori antibody was found in 643 serum samples (72.9%). Among cardiometabolic risk factors, only the mean weight of participants was different between two groups (44.6±11.8 in H. pylori positive and 42.8±11.3 in H. pylori negative group; p=0.04). Overall, 5.1% of adolescents with positive H. pylori tests were overweight or obese, while 1.7% of negative ones were so (p=0.02). In the multivariate regression model, H. pylori seropositivity increased the risk of overweight (OR, 3.3; 95%CI, 1.2-9.3; p=0.03). In the multivariate model, association of other cardiometabolic risk factors with H. pylori infection was not statistically significant (p>0.05).
Conclusion: Results of present study showed that H. pylori infection was associated with excess weight in adolescents. H. pylori eradication may be decrease the risk of obesity.

 
Keyword(s): ADOLESCENT, HELICOBACTER PYLORI, IRAN, METABOLIC SYNDROME
 
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