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Paper Information

Journal:   MODARES MECHANICAL ENGINEERING   FEBRUARY 2017 , Volume 16 , Number 11 ; Page(s) 255 To 265.
 
Paper: 

SIMULATION OF HEPARIN DISTRIBUTION IN AN INJURED CORONARY ARTERY

 
 
Author(s):  VAHEDI SEYED MASOUD, VALIPOUR MOHAMMAD SADEGH*, DE MONTE FILIPPO
 
* FACULTY OF MECHANICAL ENGINEERING, SEMNAN UNIVERSITY, SEMNAN, IRAN
 
Abstract: 

Nowadays the use of Drug Eluting Stents (DESs) is considered as a successful method for the treatment of coronary artery blockage. In order to study the impact of the presence of topcoat on heparin-eluting stents efficacy, two designs (with and without drug free topcoat) have been compared. Moreover, here the importance of the plasma flow as a controversial topic among researchers has been studied. In order to have more realistic working heart, plasma flow is considered a pulsatile function. Also, the injury of the coronary artery penetrated to a depth of media layer during angioplasty. Volume-averaged porous media equations which describe the drug release dynamics are employed and solved numerically by Finite Volume Method (FVM). Results put the amount of strut penetration in the forefront of importance. Local drug pharmacokinetics experiences significant changes by strut passing through endothelium, intima and Internal Elastic Lamina (IEL) and being contiguous with media layer.
Although the plasma flow decreases/increases the amount of concentration level and subsequently decreases/increases the amount of drug mass in media/adventitia layer, the results show that these effects are not significant. Among other findings, it is notable that the presence of topcoat has a negligible effect on the release characteristics.

 
Keyword(s): DRUG ELUTING STENTS (DESS), DRUG DELIVERY, ATHEROSCLEROSIS, POROUS MEDIA, PHARMACOKINETICS
 
References: 
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