Paper Information

Journal:   MODARES MECHANICAL ENGINEERING   FEBRUARY 2017 , Volume 16 , Number 11 #F0072; Page(s) 61 To 68.
 
Paper:  COMPARISON OF QUANTITATE 18F-FDG UPTAKE METHODS BY USING COMPARTMENTAL MODELING
 
Author(s):  AHMADVAND MAHDI, MAFI MOSTAFA, SEFIDGAR MOSTAFAR*, SOLTANI MAJID
 
* DEPARTMENT OF MECHANICAL ENGINEERING, PARDIS BRANCH, ISLAMIC AZAD UNIVERSITY, PARDIS, IRAN
 
Abstract: 

Nowadays, use of modified compartmental model in order to estimate the transmission of tracer to the cells or cancerous tissues is used extensively. The modified compartmental model includes two parts, one to predict the mass transfer from vessels and a compartment to describe metabolism occurring inside the tissue. In the modified compartmental model, the kinetic rate constants can be obtained by estimating the parameters between the compartments. The tracer uptake is the main method used to diagnosis of cancerous tissues from other tissues. Today, most physicians use the standard uptake value (SUV) to study the amount of tracer uptake in cancer suspicious regions in order to have a more accurate recognition of cancerous and normal tissues. In this paper, the comprehensive evaluation of different uptake methods based on experimental data is performed. The Patlak graphical analysis method and standard uptake value method are used to predict the tracer uptake into the tissue. A comparison between the uptake parameter resulted from the two mentioned methods with the uptake parameter obtained by modified compartmental model in a rat shows the appropriate degree of accuracy of the Patlak method in distinguishing the cancerous tissues from the normal ones.

 
Keyword(s): MODIFIED COMPARTMENTAL MODEL, PATLAK GRAPHICAL ANALYSIS, STANDARD UPTAKE VALUE, POSITRON EMISSION TOMOGRAPHY
 
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