Paper Information

Journal:   IRANIAN JOURNAL OF TOXICOLOGY   MAY-JUNE 2018 , Volume 12 , Number 3; Page(s) 51 To 58.
 
Paper: 

FREE RADICAL SCAVENGING, ANTIMICROBIAL ACTIVITIES AND EFFECT OF SUB-ACUTE EXPOSURE TO NIGERIANXYLOPIA AETHIOPICA SEED EXTRACT ON LIVER AND KIDNEY FUNCTIONAL INDICES OF ALBINO RAT

 
 
Author(s):  YUSUF ABUBAKAR AWWAL, LAWAL BASHIR*, ABDULGANEEY YUSUF MUMEEN, OMONIJE YEMISI OMOTAYO, ADEJOKE AROGBOKUN OPEYEMI, RAJI FEYISARA HABIBAT, WENAWO DANNANA LUKE
 
* DEPARTMENT OF BIOCHEMISTRY, FEDERAL UNIVERSITY OF TECHNOLOGY, MINNA, NIGERIA
 
Abstract: 

Background: Xylopia aethiopica is highly reputed for its numerous medicinal properties. In the present study, antioxidant, antimicrobial, and toxicity profile of methanol seed extract of NigerianX. aethiopicain rat were evaluated.
Methods: Phytochemical compositions were evaluated using standard procedures. The antibacterial study was carried out using agar well diffusion method, while antioxidant activities were evaluated by DPPH and FRAP assay. Twenty-five rats (5 each) were given 0, 75, 150, 300 and 600 mg/kg bwt of the extract orally for 28 days.
Results: The extract had total phenolic and total flavonoid contents of 15.98
±0.03mg GAE/g and 2.29±0.02 mg/g CE respectively. The extract had IC50 values of 52.45±3.05 mg/mL and 73.45±3.89 mg/mL in DPPH and FRAP assay respectively. The E. coli showed the highest susceptibility (20.27±0.90mm) while P. aeuruginisa showed the least (15.08±0.20mm). The MIC ranged from 25-50 mg/mL while MBC ranged between 50mg/mL and 100 mg/mL. In comparison with the control rats, the levels of serum creatinine, bicarbonate total proteins, albumin, and ALP were significantly higher in rat dosed 600 mg/kg bwt while urea decreases in rat dose 300 and 600 mg/kg. However, serum concentration of ALT, AST, bilirubin, Na+, K+ and Cl- compared favorably (P>0.05) with control at all doses.
Conclusion: The study revealed the antioxidant and antimicrobial activities of Nigerian X. aethiopica, the extract at 75, 150 and 300 mg/kg/b.wt did not provoke toxic effects to the animals’ liver and kidney; however, caution should be exercised when using as a prolonged oral remedy at high doses.

 
Keyword(s): ANTIBACTERIAL, ANTI-OXIDANTS, FLAVONOIDS XYLOPIA AETHIOPICA, PHENOLICS, TOXICITY
 
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