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Paper Information

Journal:   IRANIAN JOURNAL OF TOXICOLOGY   MAY-JUNE 2018 , Volume 12 , Number 3; Page(s) 21 To 27.
 
Paper: 

POST EXPOSURE EFFECTS OF PROPOXUR (AGRICULTURAL PESTICIDE) ON MALE FERTILITY IN WISTAR RAT

 
 
Author(s):  KENFACK AUGUSTAVE, NANTIA EDOUARD AKONO*, NGOULA FERDINAND, GUIEKEP NOUNAMO ARTHENICE JEMIMA, KAMTCHOUING PIERRE, TCHOUMBOUE JOSEPH
 
* DEPARTMENT OF BIOCHEMISTRY, FACULTY OF SCIENCE, UNIVERSITY OF BAMENDA, BAMBILI, CAMEROON
 
Abstract: 

Background: Contamination of fruit juices with heavy metals presents a risk for human health.
Concentrations of lead, and arsenic in fruit juices of market in Mashhad, Iran, were measured using atomic absorption spectrometry (AAS).
Methods: Fifty varieties of commercial fruit j

Background: Pesticide toxicity is one of the major environmental health problems for the modern societies, as some of the effects may last long time after exposure. Propoxur is one of the Carbamate pesticide largely used in agriculture in the Western region of Cameroon.
Methods: In order to evaluate the post-exposure effects of propoxur, 48 male rats (12 animals per group) aged 30 d were orally gavaged with 0.00, 1.73, 2.60 and 5.20 mg.kg-1 body weight of propoxur for 90 d. At the end of treatment, 6 rats per group were sacrificed and others were followed up for 90 additional days and submitted to a fertility test before sacrifice.
Results: At the end of exposure propoxur significantly increased (P<0.05) the testis weight while it decreased (P<0.05) the cauda epididymal sperm motility in rat. Propoxur treatment and post-treatment exposure showed variable effect on the fertility rate with an increase and decrease at 2.60 and 5.20 mg.kg-1, respectively. At the 90th day post treatment, there was a significant decrease (P<0.05) in epididymis weight and sperm count and motility (P<0.05). In addition, post-exposure treatment with propoxur reduced (P<0.05) the pup litter size and the sex ratio at all doses. Histopathological examination revealed a high vacuity of germinal epithelia in treated rats that persisted after post-exposure time.
Conclusion: Propoxur negatively affected male rats’ reproductive parameters with more significant adverse effects observed 90 d after the end of exposure.

 
Keyword(s): FERTILITY, MALE RATS, POST-EXPOSURE EFFECTS, PROPOXUR, REPRODUCTIVE PARAMETERS
 
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