Paper Information

Journal:   IRANIAN JOURNAL OF TOXICOLOGY   MAY-JUNE 2018 , Volume 12 , Number 3; Page(s) 1 To 8.
 
Paper:  HISTOPATHOLOGICAL STUDY OF PROTECTIVE EFFECTS OF HONEY ON SUBACUTE TOXICITY OF ACRYLAMIDE-INDUCED TISSUE LESIONS IN RATS’ BRAIN AND LIVER
 
Author(s):  AHRARI ROODI PARICHEHR, MOOSAVI ZAHRA*, AFKHAMI GOLI AMIR, AZIZZADEH MOHAMMAD, HOSSEINZADEH HOSSEIN
 
* DEPARTMENT OF PATHOBIOLOGY, FACULTY OF VETERINARY MEDICINE, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Abstract: 

Background: The therapeutic potential of honey is related to antioxidant activity against reactive oxygen species because it contains compounds such as polyphenols; therefore, we evaluated the potential protective effect of honey on subacute toxicity of ACR by histopathologic study on tissue lesions in rat.
Methods: In Ferdowsi University of Mashhad, Mashhad, Iran, 2016, male Wistar rats were divided into 7 groups. To induce toxicity, ACR was injected (50 mg/kg for 11 d) to rats in 5 groups. In treatment groups, rats received three doses of honey 1.25, 2.5, and 5 g/kg in addition to the ACR. The two remaining groups received vitamin E (200 IU/kg) and normal saline as positive and negative control respectively. On the last day, after necropsy, tissue specimens from brain and liver were collected for histopathological studies.
Results: Receiving of ACR caused tissue injuries including degeneration, necrosis, hyperemia, hemorrhage and inflammation in liver; ischemic cell change, hyperemia, hemorrhage and edema in brain tissue. Administration of honey considerably reduced tissue damages caused by ACR, particularly with dosage 5 g/kg.
Conclusion: The severity of tissue lesions caused by the ACR can be reduced by honey, likely through its antioxidant activity. Increasing concentrations of honey will enhance its effectiveness.

 
Keyword(s): ACRYLAMIDE, HISTOPATHOLOGY, HONEY, WISTAR RAT
 
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