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Paper Information

Journal:   JOURNALS OF HERBMED PHARMACOLOGY   2018 , Volume 7 , Number 2 ; Page(s) 100 To 105.
 
Paper: 

ANTISPASMODIC ACTIVITY OF APIGENIN AND LUTEOLIN, TWO COMPONENTS OF DRACOCEPHALUM KOTSCHYI EXTRACT, ON RAT ILEUM CONTRACTIONS

 
 
Author(s):  SADRAEI HASSAN*, GHANADIAN MOSTAFA, ASGHARI GHOLAMREZA, SEKHAVATI NASTARAN
 
* DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, SCHOOL OF PHARMACY AND PHARMACEUTICAL SCIENCES, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Introduction: Aerial parts of Dracocephalum kotschyi have been used as antispasmodic agents in Iranian traditional medicine. Recent pharmacological studies confirmed antispasmodic activity of D. kotschyi extract. The objective of this research was to investigate antispasmodic activities of apigenin and luteolin to find out if they are responsible for the spasmolytic activity of hydroalcoholic extract of D. kotschyi.
Methods: Aerial parts of D. kotschyi were extracted with ethanol. Antispasmodic effect of hydroalcoholic extract of D. kotschyi, apigenin and luteolin were examined on KCl and/or acetylcholine (ACh) -induced contractions in rat isolated ileum.
Results: Hydroalcoholic extract of D. kotschyi concentrations-dependently inhibited KCl and ACh induced contractions with IC50 values of 41 ± 10
mg/mL and 133 ± 19 mg/mL, respectively. Apigenin concentrations-dependently inhibited KCl and ACh induced contractions with IC50 values of 57 ± 12 mM and 80 ± 18 mM, respectively. Luteolin concentrations-dependently inhibited KCl induced contractions with IC50 values of 68 ± 14 mM. Loperamide reduced both KCl and ACh induced contraction with IC50 values of 189 ± 44 nM and 82 ± 20 mM, respectively.
Conclusion: In this study apigenin and luteolin were identified as two active ingredients responsible for antispasmodic activities of D. kotschyi extract.

 
Keyword(s): APIGENIN, LUTEOLIN, DRACOCEPHALUM KOTSCHYI, MEDICINAL PLANTS, ILEUM, ANTISPASMODIC ACTIVITY
 
 
References: 
 
Citations: 
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APA: Copy

SADRAEI, H., & GHANADIAN, M., & ASGHARI, G., & SEKHAVATI, N. (2018). ANTISPASMODIC ACTIVITY OF APIGENIN AND LUTEOLIN, TWO COMPONENTS OF DRACOCEPHALUM KOTSCHYI EXTRACT, ON RAT ILEUM CONTRACTIONS. JOURNALS OF HERBMED PHARMACOLOGY, 7(2 ), 100-105. https://www.sid.ir/en/journal/ViewPaper.aspx?id=571207



Vancouver: Copy

SADRAEI HASSAN, GHANADIAN MOSTAFA, ASGHARI GHOLAMREZA, SEKHAVATI NASTARAN. ANTISPASMODIC ACTIVITY OF APIGENIN AND LUTEOLIN, TWO COMPONENTS OF DRACOCEPHALUM KOTSCHYI EXTRACT, ON RAT ILEUM CONTRACTIONS. JOURNALS OF HERBMED PHARMACOLOGY. 2018 [cited 2021August04];7(2 ):100-105. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=571207



IEEE: Copy

SADRAEI, H., GHANADIAN, M., ASGHARI, G., SEKHAVATI, N., 2018. ANTISPASMODIC ACTIVITY OF APIGENIN AND LUTEOLIN, TWO COMPONENTS OF DRACOCEPHALUM KOTSCHYI EXTRACT, ON RAT ILEUM CONTRACTIONS. JOURNALS OF HERBMED PHARMACOLOGY, [online] 7(2 ), pp.100-105. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=571207.



 
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