Paper Information

Journal:   JOURNALS OF HERBMED PHARMACOLOGY   2018 , Volume 7 , Number 2 #M0075; Page(s) 94 To 99.
 
Paper: 

EFFECTS OF ZINGIBER OFFICINALE HYDRO-ALCOHOLIC EXTRACT ON HMG-COA REDUCTASE LEVEL IN THE TESTIS OF STREPTOZOTOCIN-INDUCED DIABETIC RATS

 
 
Author(s):  MORADI PODEH BAHMAN, KHEIROLLAH ALIREZA, AHMMADPOUR FATEMEH, LAMUCHI DELI NASRIN, PAYAMI SEYEDE AREFE, MOHAMMADZADEH GHORBAN*
 
* HYPERLIPIDEMIA RESEARCH CENTER, DEPARTMENT OF CLINICAL BIOCHEMISTRY, FACULTY OF MEDICINE, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Introduction: Zingiber officinale Roscoe, commonly known as ginger, is used as a cooking spice and therapeutically for its antioxidant and androgenic activities. We investigated the effects of Z. officinale hydro-alcoholic extract on HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase level in the testis of streptozotocin (STZ) -induced diabetic rats.
Methods: The current experimental study was performed on four groups of male Wistar rats one of them was kept as a healthy control, while the others were rendered diabetic via a single intraperitoneal injection of STZ (60 mg kg-1). One group was considered as diabetic control; while the others were given orally hydro-alcoholic extract (200 and 400 mg kg-1) for 56 consecutive days. Body weight, blood glucose and insulin concentrations were evaluated using standard methods. The HMG-COA reductase level was determined by western blot analysis.
Results: Treatment with the extract resulted in a significant reduction of serum glucose concentration and HMG-COA reductase level in the rat’s testis compared to diabetic controls (P<0.01). A significant increase in body weight was observed in treated diabetic rats. Also, serum insulin was significantly increased in diabetic rats treated with 400 mg/kg of the extract compared to diabetic controls (P<0.05).
Conclusion: Ginger has a potential influence on the regulation of cholesterol homeostasis by modulating of HMG-COA reductase level. The results provide scientific evidence to confirm the traditional use of Z. officinale in the treatment of diabetes mellitus.

 
Keyword(s): STREPTOZOTOCIN-INDUCED DIABETES, HMG-COA REDUCTASE, ZINGIBER OFFICINALE, MEDICINAL PLANT
 
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