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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   MARCH 2018 , Volume 43 , Number 2; Page(s) 184 To 194.
 
Paper: 

THE PREVENTIVE ROLE OF PIOGLITAZONE IN GLYCEROL-INDUCED ACUTE KIDNEY INJURY IN RATS DURING TWO DIFFERENT TREATMENT PERIODS

 
 
Author(s):  MOUSLEH RAMA, AL LAHAM SHAZA*, AL MANADILI AHMAD
 
* DEPARTMENTOF PHARMACOLOGY AND TOXICOLOGY, FACULTY OF PHARMACY, DAMASCUS UNIVERSITY, DAMASCUS, SYRIA
 
Abstract: 

Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period.
Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days). Serum urea and creatinine levels were measured to assess the renal function. Reduced glutathione (GSH) levels and histological alterations were also measured. Statistical analysis was performed using Prism (version 6). The numerical data were evaluated by ANOVA, followed by the Tukey tests. The categorical data were evaluated by the Mann–Whitney test and the Fisher exact tests. P<0.05 was considered significant.
Results: In the glycerol-injected rats, the serum urea and creatinine levels were increased (P<0.001), while the GSH levels were decreased (P<0.001) compared to Group A.
The nephrotoxicity showed significant tubular (P=0.01) and glomerular (P=0.02) injuries. In the pioglitazone-treated rats, the changes in the serum biomarkers and in the GSH levels were reversed in Group C (P=0.01) and in Group D (P=0.01).
The microscopic examinations of the kidneys also showed some improvement. No obvious statistically significant difference was found between these 2 preventive groups in most studied features.
Conclusion: These results indicate that pioglitazone might have nephroprotective effects in this injury model. Pioglitazone succeeded in producing this effect within 3 days. Doubling the drug administration period did not produce any significant superior benefit.

 
Keyword(s): KIDNEY, GLYCEROL, RHABDOMYOLYSIS, ACUTE KIDNEY INJURY, PIOGLITAZONE, REDUCED GLUTATHIONE
 
 
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APA: Copy

MOUSLEH, R., & AL LAHAM, S., & AL MANADILI, A. (2018). THE PREVENTIVE ROLE OF PIOGLITAZONE IN GLYCEROL-INDUCED ACUTE KIDNEY INJURY IN RATS DURING TWO DIFFERENT TREATMENT PERIODS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 43(2), 184-194. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570701



Vancouver: Copy

MOUSLEH RAMA, AL LAHAM SHAZA, AL MANADILI AHMAD. THE PREVENTIVE ROLE OF PIOGLITAZONE IN GLYCEROL-INDUCED ACUTE KIDNEY INJURY IN RATS DURING TWO DIFFERENT TREATMENT PERIODS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS). 2018 [cited 2021August04];43(2):184-194. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570701



IEEE: Copy

MOUSLEH, R., AL LAHAM, S., AL MANADILI, A., 2018. THE PREVENTIVE ROLE OF PIOGLITAZONE IN GLYCEROL-INDUCED ACUTE KIDNEY INJURY IN RATS DURING TWO DIFFERENT TREATMENT PERIODS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), [online] 43(2), pp.184-194. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570701.



 
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