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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   MARCH 2018 , Volume 43 , Number 2; Page(s) 195 To 201.
 
Paper: 

AMELIORATION OF PENTYLENETETRAZOLE-INDUCED SEIZURES BY MODULATORS OF SIGMA, N-METHYL-DASPARTATE, AND RYANODINE RECEPTORS IN MICE

 
 
Author(s):  KESHAVARZ MOJTABA*, YEKZAMAN BEHDAD
 
* SHIRAZ NEUROSCIENCE RESEARCH CENTER, CHAMRAN HOSPITAL, CHAMRAN BOULEVARD, SHIRAZ, IRAN
 
Abstract: 

Background: Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ) -induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol.
Methods: PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8).
Opipramole (10, 20, and 50 mg/kg), ketamine (50 mg/kg), caffeine (200 mg/kg), opipramole (20 mg/kg) plus ketamine (50 mg/kg), opipramole (20 mg/kg) plus caffeine (200 mg/kg), diazepam (5 mg/kg as a positive control), and the vehicle were administered interaperitoneally 30 minutes before the injection of PTZ. The latency was recorded for the clonic, tonic-clonic seizures, and death of animals after the injection of PTZ. Kruskal-Wallis test followed by Dunn’s test was used for the analysis of data. Statistical analysis was performed with the SPSS software version 23.0 and P<0.05 was considered as the significant level.
Results: Opipramol (20 mg/kg) increased the latency for the PTZ-induced clonic (44%, P=0.021) and tonic-clonic (130.80%, P=0.043) seizures compared with the vehicle-treated group.
Animals treated with opipramol (20 mg/kg) plus caffeine (200 mg/kg) had a significantly higher onset of PTZ-induced clonic and tonic-clonic seizures compared with the control (P=0.046 and<0.001, respectively). Ketamine combined with opipramol increased the onset of tonic-clonic seizure compared with the vehicle-treated groups (P<0.001).
Conclusion: Opipramol attenuated the seizures induced by the PTZ. Ketamine and caffeine had no effect on the anticonvulsant activity of opipramol.

 
Keyword(s): OPIPRAMOL, SIGMA, PENTYLENETETRAZOLE, KETAMINE, CAFFEINE
 
 
References: 
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Click to Cite.
APA: Copy

KESHAVARZ, M., & YEKZAMAN, B. (2018). AMELIORATION OF PENTYLENETETRAZOLE-INDUCED SEIZURES BY MODULATORS OF SIGMA, N-METHYL-DASPARTATE, AND RYANODINE RECEPTORS IN MICE. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 43(2), 195-201. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570657



Vancouver: Copy

KESHAVARZ MOJTABA, YEKZAMAN BEHDAD. AMELIORATION OF PENTYLENETETRAZOLE-INDUCED SEIZURES BY MODULATORS OF SIGMA, N-METHYL-DASPARTATE, AND RYANODINE RECEPTORS IN MICE. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS). 2018 [cited 2021May11];43(2):195-201. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570657



IEEE: Copy

KESHAVARZ, M., YEKZAMAN, B., 2018. AMELIORATION OF PENTYLENETETRAZOLE-INDUCED SEIZURES BY MODULATORS OF SIGMA, N-METHYL-DASPARTATE, AND RYANODINE RECEPTORS IN MICE. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), [online] 43(2), pp.195-201. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570657.



 
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