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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   MARCH 2018 , Volume 43 , Number 2; Page(s) 174 To 183.
 
Paper: 

URTICA DIOICA DISTILLATE REGENERATES PANCREATIC BETA CELLS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

 
 
Author(s):  GOHARI ALI, NOORAFSHAN ALI, AKMALI MASOUMEH, ZAMANI GARMSIRI FAHIMEH, SEGHATOLESLAM ATEFEH*
 
* DEPARTMENT OF BIOCHEMISTRY, SCHOOL OF MEDICINE, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Background: Urtica dioica is known as an anti-hyperglycemic plant.
Urtica dioica distillate (UD) is a traditional Iranian drink, locally known as “aragh gazaneh”. In spite of its widespread consumption in Iran, according to traditional Iranian medicine, there is no scientific report on the usefulness of UD for diabetic patients. This survey was designed to evaluate its protective effects for the recovery from diabetes by determining the serum insulin, blood glucose, volume of pancreatic islets, and the number and volume of
b-cells in diabetic rats.
Methods: A total of 48 Sprague-Dawley male rats (200-250 g) were randomly distributed into 6 groups (n=8), including nondiabetic plus distilled water (DW), non-diabetic plus UD, diabetic plus DW, diabetic plus UD, diabetic plus insulin, and diabetic plus glibenclamide. DW, UD, and glibenclamide were administered via intragastric gavage and insulin was injected subcutaneously. After four weeks of experiments, blood samples were collected for serum insulin and blood glucose assay.
Pancreas was also evaluated using stereological method. The SPSS software was used for statistical analysis. Kruskal-Wallis, repeated measurements, and Mann-Whitney U test were applied for comparisons between the groups.
Results: The treatment of diabetic rats with UD reduced the blood glucose dramatically (P<0.001) and increased serum insulin levels significantly (P=0.03) in comparison to the diabetic plus DW rats. Treatment with UD did not affect the mean
b-cell volumes in the diabetic rats when compared to the diabetic plus DW rats, but the islet volumes and ?-cell numbers were significantly recovered.
Conclusion: UD treatment in diabetic rats improves hyperglycemia by partially restoring plasma insulin levels. The data suggest that UD prevents islet atrophy and/or regenerate pancreatic
b-cells.

 
Keyword(s): DIABETES MELLITUS, PANCREATIC BETA CELL, URTICA DIOICA DISTILLATE, RATS, STREPTOZOTOCIN
 
 
References: 
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Click to Cite.
APA: Copy

GOHARI, A., & NOORAFSHAN, A., & AKMALI, M., & ZAMANI GARMSIRI, F., & SEGHATOLESLAM, A. (2018). URTICA DIOICA DISTILLATE REGENERATES PANCREATIC BETA CELLS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 43(2), 174-183. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570644



Vancouver: Copy

GOHARI ALI, NOORAFSHAN ALI, AKMALI MASOUMEH, ZAMANI GARMSIRI FAHIMEH, SEGHATOLESLAM ATEFEH. URTICA DIOICA DISTILLATE REGENERATES PANCREATIC BETA CELLS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS). 2018 [cited 2021May08];43(2):174-183. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570644



IEEE: Copy

GOHARI, A., NOORAFSHAN, A., AKMALI, M., ZAMANI GARMSIRI, F., SEGHATOLESLAM, A., 2018. URTICA DIOICA DISTILLATE REGENERATES PANCREATIC BETA CELLS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), [online] 43(2), pp.174-183. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570644.



 
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