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Paper Information

Journal:   JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   2016 , Volume 18 , Number 3 ; Page(s) 78 To 86.
 
Paper: 

PREDICTING OF DISEASE FREE SURVIVAL IN PATIENTS WITH THYROID CANCER AND ITS INFLUENCING FACTORS DURING 1978 TO 2012

 
 
Author(s):  FARDMAL J., GHAFARI M.E., ZAKAVI S.R., ROSHNAEI GH.*, JAVANROH N.
 
* BIOSTATICS DEPT., HAMEDAN UNIVERSITY OF MEDICAL UNIVERSITY, HAMEDAN, I.R. IRAN
 
Abstract: 

Background and aims: Thyroid cancer is a malignancy of the endocrine system that its incidence has been raising steadily in many parts of the world. Regarding to existence of many factors affecting on disease-free survival in patients suffering from thyroid cancer, this study was aimed to identify this factors.
Methods: In this historical cohort study, 785 cases of differentiated thyroid cancer patients referred nuclear medicine wards of Imam Reza and Ghaem hospitals, Mashhad during the 1978-2012 were assessed. The follow-up of all patients was performed through periodic visits and telephone. The effect of various demographic and clinical factors on disease free survival of patients was evaluated using Weibull regression model.
Results: The median disease-free survival time of patients was resulted in 15±1.05 years. Evaluating the clinical and pathological features using univariate analysis showed that the impact of gender, age at diagnosis, type of cancer, stage of cancer, type of treatment, the primary of Thymoglobulin, size of motor, the status of involved Lymph nodes and status of metastasis, incomplete surgery had a significant association with disease free survival of patients (P<0.05). Moreover, in the multivariate case, size of motor, the status of involved Lymph nodes, status of metastasis and age at diagnosis was significant and had a significant association with disease free survival of patients (P<0.05).
Conclusion: Regarding to the numerous factors that impact the risk of recurrence and affect the status of metastasis, size of motor and the status of involved Lymph nodes and age at diagnosis at the moderate status, it seems that those with distant metastases as well as those in the fourth stages and aged over 45 years are at greater risk of recurrence.

 
Keyword(s): THYROID CANCER, DISEASE-FREE SURVIVAL ANALYSIS, WEIBULL MODEL
 
 
References: 
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Citations: 
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APA: Copy

FARDMAL, J., & GHAFARI, M., & ZAKAVI, S., & ROSHNAEI, G., & JAVANROH, N. (2016). PREDICTING OF DISEASE FREE SURVIVAL IN PATIENTS WITH THYROID CANCER AND ITS INFLUENCING FACTORS DURING 1978 TO 2012. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 18(3 ), 78-86. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570639



Vancouver: Copy

FARDMAL J., GHAFARI M.E., ZAKAVI S.R., ROSHNAEI GH., JAVANROH N.. PREDICTING OF DISEASE FREE SURVIVAL IN PATIENTS WITH THYROID CANCER AND ITS INFLUENCING FACTORS DURING 1978 TO 2012. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES. 2016 [cited 2021August02];18(3 ):78-86. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570639



IEEE: Copy

FARDMAL, J., GHAFARI, M., ZAKAVI, S., ROSHNAEI, G., JAVANROH, N., 2016. PREDICTING OF DISEASE FREE SURVIVAL IN PATIENTS WITH THYROID CANCER AND ITS INFLUENCING FACTORS DURING 1978 TO 2012. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, [online] 18(3 ), pp.78-86. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570639.



 
 
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