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Paper Information

Journal:   THE JOURNAL OF NEPHRO-UROLOGY MONTHLY   NOVAMBER 2016 , Volume 8 , Number 6; Page(s) 0 To 0.
 
Paper: 

PROSTATE-SPECIFIC ANTIGEN DENSITY AND GLEASON SCORE PREDICT ADVERSE PATHOLOGIC FEATURES IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER

 
 
Author(s):  NOWROOZI MOHAMMAD REZA, MOMENI SEYED ALI*, OHADIAN MOGHADAM SOLMAZ, AYATI ELNAZ, MORTAZAVI AFSHIN, ARFAE SIMIN, JAMSHIDIAN HASSAN, TAHERIMAHMOUDI MOHSEN, AYATI MOHSEN
 
* URO-ONCOLOGY RESEARCH CENTER, EMAM KHOMEINI HOSPITAL, TOHID SQ., TEHRAN, IR IRAN
 
Abstract: 

Background: According to recent studies, prostate cancer is the second most common cancer among Iranian men. Radical prostatectomy has been considered the gold standard treatment in patients with clinically localized prostate cancer. Gleason score, PSA density, and PSA velocity are some of the parameters used to predict adverse pathologic features.
Objectives: The aim of this study was to evaluate the prognostic value of PSA density and Gleason score in predicting adverse pathologic features in patients with localized prostate cancer who undergo radical prostatectomy.
Methods: We conducted a cross-sectional study of 105 patients with localized prostate cancer who under went radical prostatectomy between2006and2013.We recorded Gleason scores and PSA levels, in addition to the results of pathological evaluations after radical prostatectomy, including prostate volume, stage, LNI (lymph node involvement), SVI (seminal vesicle invasion), and extra prostatic extension (EPE). Data were analyzed using SPSS version 21.
Results: Mean PSA density was 0.27 (0.17 SD). The frequencies of EPE, SVI, and LNI were 21.9, 16.2, and 2.9, respectively. The Mann-Whitney U-test demonstrated a significant correlation between PSA density and adverse pathologic features (EPE, SVI, and LNI).
Conclusions: PSA, PSA density, and Gleason score should be considered together in order to more accurately predict the adverse pathologic features of prostate cancer.

 
Keyword(s): PROSTATE NEOPLASM, ADVERSE PATHOLOGIC FEATURE, PSA DENSITY
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

NOWROOZI, M., & MOMENI, S., & OHADIAN MOGHADAM, S., & AYATI, E., & MORTAZAVI, A., & ARFAE, S., & JAMSHIDIAN, H., & TAHERIMAHMOUDI, M., & AYATI, M. (2016). PROSTATE-SPECIFIC ANTIGEN DENSITY AND GLEASON SCORE PREDICT ADVERSE PATHOLOGIC FEATURES IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 8(6), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570609



Vancouver: Copy

NOWROOZI MOHAMMAD REZA, MOMENI SEYED ALI, OHADIAN MOGHADAM SOLMAZ, AYATI ELNAZ, MORTAZAVI AFSHIN, ARFAE SIMIN, JAMSHIDIAN HASSAN, TAHERIMAHMOUDI MOHSEN, AYATI MOHSEN. PROSTATE-SPECIFIC ANTIGEN DENSITY AND GLEASON SCORE PREDICT ADVERSE PATHOLOGIC FEATURES IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY. 2016 [cited 2021July24];8(6):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570609



IEEE: Copy

NOWROOZI, M., MOMENI, S., OHADIAN MOGHADAM, S., AYATI, E., MORTAZAVI, A., ARFAE, S., JAMSHIDIAN, H., TAHERIMAHMOUDI, M., AYATI, M., 2016. PROSTATE-SPECIFIC ANTIGEN DENSITY AND GLEASON SCORE PREDICT ADVERSE PATHOLOGIC FEATURES IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, [online] 8(6), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570609.



 
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