Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   SUMMER 2018 , Volume 20 , Number 2; Page(s) 250 To 258.
 
Paper: 

ADVANCED GLYCATION END-PRODUCTS-, C-TYPE LECTIN- AND CYSTEINYL/ LEUKOTRIENE-RECEPTORS IN DISTINCT MESENCHYMAL STROMAL CELL POPULATIONS: DIFFERENTIAL TRANSCRIPTIONAL PROFILES IN RESPONSE TO INFLAMMATION

 
 
Author(s):  NAJAR MEHDI, FAYYAD KAZAN MOHAMMAD, RAICEVIC GORDANA, FAYYAD KAZAN HUSSEIN*, MEULEMAN NATHALIE, BRON DOMINIQUE, LAGNEAUX LAURENCE
 
* LABORATORY OF CANCER BIOLOGY AND MOLECULAR IMMUNOLOGY, FACULTY OF SCIENCES I, LEBANESE UNIVERSITY, HADATH, LEBANON
 
Abstract: 

Objective: We aimed at characterizing the transcription profiles of immunological receptors associated with the biology of mesenchymal stromal cells (MSCs).
Materials and Methods: In this experimental study, quantitative real time-polymerase chain reaction (qRTPCR) was performed to establish the transcription profiles of advanced glycation end-products (RAGE) receptor, C-type lectin receptors (CLRs, including DECTIN-1, DECTIN-2 and MINCLE), leukotriene B4 (LTB4) receptors (BLT1 and BLT2) and cysteinyl leukotrienes (CysLTs) receptors (CYSLTR1 and CYSLTR2) in distinct populations of MSCs grown under basic or inflammatory conditions.
Results: MSCs derived from adipose tissue (AT), foreskin (FSK), Wharton’s jelly (WJ) and bone marrow (BM) exhibited significantly different transcription levels for these genes. Interestingly, these transcription profiles substantially changed following exposure of MSCs to inflammatory signals.
Conclusion: Collectively, for the first time, our data highlights that MSCs depending on their tissue-source, present several relevant receptors potentially involved in the regulation of inflammatory and immunological responses. Understanding the roles of these receptors within MSCs immunobiology will incontestably improve the efficiency of utilization of MSCs during cell-based therapies.

 
Keyword(s): ADVANCED GLYCATION END-PRODUCTS RECEPTOR, C-TYPE LECTIN RECEPTORS, INFLAMMATION, MESENCHYMAL STROMAL CELLS
 
References: 
 
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