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Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   SUMMER 2018 , Volume 20 , Number 2; Page(s) 150 To 156.
 
Paper: 

TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT

 
 
Author(s):  ROUIGARI MAEDEH, DEHBASHI MOEIN, GHAEDI KAMRAN, POURHOSSEIN MERAJ*
 
* HEZAR JARIB STREET, DEPARTMENT OF GENETICS AND MOLECULAR BIOLOGY, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Objective: For the first time, we used molecular signaling pathway enrichment analysis to determine possible involvement of miR-126 and IRS-1 in neurotrophin pathway.
Materials and Methods: In this prospective study, validated and predicted targets (targetome) of miR-126 were collected following searching miRtarbase (http://mirtarbase.mbc.nctu.edu.tw/) and miRWalk 2.0 databases, respectively. Then, approximate expression of miR-126 targeting in Glioma tissue was examined using UniGene database (http://www.ncbi. nlm.nih.gov/unigene). In silico molecular pathway enrichment analysis was carried out by DAVID 6.7 database (http://david. abcc.ncifcrf.gov/) to explore which signaling pathway is related to miR-126 targeting and how miR-126 attributes to glioma development.
Results: MiR-126 exerts a variety of functions in cancer pathogenesis via suppression of expression of target gene including PI3K, KRAS, EGFL7, IRS-1 and VEGF. Our bioinformatic studies implementing DAVID database, showed the involvement of miR-126 target genes in several signaling pathways including cancer pathogenesis, neurotrophin functions, Glioma formation, insulin function, focal adhesion production, chemokine synthesis and secretion and regulation of the actin cytoskeleton.
Conclusion: Taken together, we concluded that miR-126 enhances the formation of glioma cancer stem cell probably via down regulation of IRS-1 in neurotrophin signaling pathway.

 
Keyword(s): EGFL7, GLIOMA, IRS-1, MIR-126, NEUROTROPHIN
 
 
References: 
 
Click to Cite.
APA: Copy

Rouigari, M., & DEHBASHI, M., & GHAEDI, K., & POURHOSSEIN, M. (2018). TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT. CELL JOURNAL (YAKHTEH), 20(2), 150-156. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570500



Vancouver: Copy

Rouigari Maedeh, DEHBASHI MOEIN, GHAEDI KAMRAN, POURHOSSEIN MERAJ. TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT. CELL JOURNAL (YAKHTEH). 2018 [cited 2021May11];20(2):150-156. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570500



IEEE: Copy

Rouigari, M., DEHBASHI, M., GHAEDI, K., POURHOSSEIN, M., 2018. TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT. CELL JOURNAL (YAKHTEH), [online] 20(2), pp.150-156. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570500.



 
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