Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   SUMMER 2018 , Volume 20 , Number 2; Page(s) 138 To 149.
 
Paper: 

TESTOSTERONE REDUCES SPINAL CORD INJURY-INDUCED EFFECTS ON MALE REPRODUCTION BY PREVENTING CADM1 DEFECT

 
 
Author(s):  CHOOBINEH HAMID, KAZEMI MAHSA, SADIGHI GILANI MOHAMMAD ALI, HEYDARI TAHEREH, SHOKRI SAEED, BAZRAFKAN MAHSHID, HASSANZADEH GHOLAMREZA*
 
* DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Objective: This study evaluated the effects of exogenous testosterone molecule-1 (CADM1) pathological defect during early and chronic periods of spinal cord injury (SCI).
Materials and Methods: In this experimental study, testosterone was administered immediately or after one week of SCI induction. Along with quantification of CADM1 gene expression and its immunoreactivity, we evaluated sperm parameters and serum testosterone level post-SCI.
Results: Different grades of abnormalities in sperm parameters and testis architecture were observed along with significant reductions in the level of CADM1 expression and its immunoreactivity in the seminiferous tubules of both acute and chronic SCI groups. Exogenous testosterone, by compensating the serum testosterone level. Reduced the percentage of apoptotic and both short head and abnormal sperm froms in the caudal epididymis. Importantly, the beneficial effects of immediate administration of testosterone were prominent. Increases in the level of CADM1 transcription and its immunoreactivity in the testis of SCI mice treated with testosterone were accompanied by improvement of sperm motility as well as testicular Johnsen’s and Miller’s criteria.
Conclusion: Since immediate testosterone treatment improved the immunoreactivity and transcription level of CADM1, the observed beneficial effect of exogenouse testosterone can be attributed to its effect on CADM1 dynamics.

 
Keyword(s): CELL ADHESION MOLECULE, SPERM, SPINAL CORD INJURY, TESTIS, TESTOSTERONE
 
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