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Paper Information

Journal:   RESEARCH JOURNAL OF PHARMACOGNOSY   2016 , Volume 3 , Number 4; Page(s) 59 To 65.
 
Paper: 

EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY

 
 
Author(s):  MOJARRAB M., EMAMI S.A., GHEIBI SH., TALEB A.M., HESHMATI AFSHAR F.*
 
* DRUG APPLIED RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Background and objectives: The plants of genus Artemisia (Asteraceae) have been conventionally used for prevention and medication of a number of ailments. In the present research, ten extracts with different polarities from aerial parts of two Artemisia species, A. kopetdaghensis and A. turcomanica were evaluated for their potential anti-malarial properties.
Methods: The plant materials were extracted successively with petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAC), ethanol, and ethanol-water (1: 1 v/v) by cold maceration method. Cell free
b -hematin formation assay were used for assessing anti-malarial activity of obtained extracts.
Results: DCM extract of A. kopetdaghensis and PE extract of A. turcomanica showed remarkable anti-malarial activity with IC50 values of 1.04±0.02 mg/mL and 0.90±0.27 mg/mL, respectively, compared to positive control (chloroquine, IC50 0.04±0.01 mg/mL).
Conclusion: It seems that the anti-malarial activity of these extracts might be bound up with the presence of compounds with low or medium polarity; hence, this preliminary test indicated that these potent extracts could be considered for further investigations to find new sources of anti-malarial phytochemicals.

 
Keyword(s): ANTI-MALARIA, ARTEMISIA KOPETDAGHENSIS, ARTEMISIA TURCOMANICA, CELL-FREE β-HEMATION FORMATION ASSAY
 
 
References: 
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+ Click to Cite.
APA: Copy

MOJARRAB, M., & EMAMI, S., & GHEIBI, S., & TALEB, A., & HESHMATI AFSHAR, F. (2016). EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY. RESEARCH JOURNAL OF PHARMACOGNOSY, 3(4), 59-65. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570441



Vancouver: Copy

MOJARRAB M., EMAMI S.A., GHEIBI SH., TALEB A.M., HESHMATI AFSHAR F.. EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY. RESEARCH JOURNAL OF PHARMACOGNOSY. 2016 [cited 2021May16];3(4):59-65. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570441



IEEE: Copy

MOJARRAB, M., EMAMI, S., GHEIBI, S., TALEB, A., HESHMATI AFSHAR, F., 2016. EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY. RESEARCH JOURNAL OF PHARMACOGNOSY, [online] 3(4), pp.59-65. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570441.



 
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