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Paper Information

Journal:   RESEARCH JOURNAL OF PHARMACOGNOSY   2016 , Volume 3 , Number 4; Page(s) 39 To 49.
 
Paper: 

NEUROPROTECTION AND ANXIETY LIKE BEHAVIOR REDUCTION OF ALLIUM HIRTIFOLIUM AND ASTRAGALUS HAMOSUS IN THE Aβ-INJECTED RAT

 
 
Author(s):  BAHAEDDIN Z., YANS A., KHODAGHOLI F., SAHRANAVARD S.*
 
* TRADITIONAL MEDICINE AND MATERIA MEDICA RESEARCH CENTER AND DEPARTMENT OF TRADITIONAL PHARMACY, SCHOOL OF TRADITIONAL MEDICINE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background and objectives: Traditional medicine is an important approach to achieve new therapeutic strategies in basic and clinical pharmacology. Allium hirtifolium Boiss. and Astragalus hamosus L. have been mentioned in Iranian Traditional Medicine references for a kind of dementia with features and symptoms similar to those of Alzheimer's disease (AD). In the present study, the neuroprotective effect of these herbs has been evaluated as new therapies in neurotoxicity model.
Methods: Two separate groups of rats were fed with A. hirtifolium or A. hamosus extract (100 mg/kg/day) from 1 week before amyloid beta (A
b) injection, for 16 consecutive days. One day after the last oral administration, behavioral test was done. The effect of these two extracts were assessed in anxiety-like behavior test using elevated plus maze. Furthermore, molecular pathways involved in apoptosis were assessed by Western blotting analysis.
Results: The results showed that oral administration of both A. hirtifolium and A. hamosus decreased anxiety-like behavior and ameliorated the effect on apoptosis factors including Bax, Bcl-2 and caspase-3 in the rats with intra-hippocampal injection of A
b.
Conclusion: The results of this study revealed the potential neuroprotective properties of A. hirtifolium and A. hamosus as herbal remedies that could play a role in fostering healthy aging and be considered as useful candidates in decreasing AD related symptoms.

 
Keyword(s): ALLIUM HIRTIFOLIUM, ALZHEIMER'S DISEASE, ANXIETY, APOPTOSIS, ASTRAGALUS HAMOSUS
 
 
References: 
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Click to Cite.
APA: Copy

BAHAEDDIN, Z., & YANS, A., & KHODAGHOLI, F., & SAHRANAVARD, S. (2016). NEUROPROTECTION AND ANXIETY LIKE BEHAVIOR REDUCTION OF ALLIUM HIRTIFOLIUM AND ASTRAGALUS HAMOSUS IN THE Aβ-INJECTED RAT. RESEARCH JOURNAL OF PHARMACOGNOSY, 3(4), 39-49. https://www.sid.ir/en/journal/ViewPaper.aspx?id=570424



Vancouver: Copy

BAHAEDDIN Z., YANS A., KHODAGHOLI F., SAHRANAVARD S.. NEUROPROTECTION AND ANXIETY LIKE BEHAVIOR REDUCTION OF ALLIUM HIRTIFOLIUM AND ASTRAGALUS HAMOSUS IN THE Aβ-INJECTED RAT. RESEARCH JOURNAL OF PHARMACOGNOSY. 2016 [cited 2021May11];3(4):39-49. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570424



IEEE: Copy

BAHAEDDIN, Z., YANS, A., KHODAGHOLI, F., SAHRANAVARD, S., 2016. NEUROPROTECTION AND ANXIETY LIKE BEHAVIOR REDUCTION OF ALLIUM HIRTIFOLIUM AND ASTRAGALUS HAMOSUS IN THE Aβ-INJECTED RAT. RESEARCH JOURNAL OF PHARMACOGNOSY, [online] 3(4), pp.39-49. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=570424.



 
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