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Paper Information

Journal:   IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)   AUGUST-SEPTEMBER 2016 , Volume 19 , Number 3 ; Page(s) 457 To 481.
 
Paper: 

THE STRUCTURE AND MODE OF ACTION OF THE DINOFLAGELLATE TOXINS

 
DOI: 

10.18869/acadpub.ismj.19.3.457

 
Author(s):  NAJAFI A.*, NABIPOUR I.
 
* THE PERSIAN GULF MARINE BIOTECHNOLOGY RESEARCH CENTER, THE PERSIAN GULF BIOMEDICAL SCIENCES RESEARCH INSTITUTE, BUSHEHR UNIVERSITY OF MEDICAL SCIENCES, BUSHEHR, IRAN
 
Abstract: 

Background: Dinoflagellates are the major causative agents of harmful algal blooms. In different studies, it has been shown that many dinoflagellate species produce various natural toxins. Saxitoxin, brevetoxin, yessotoxin, etc can be considered as the most important neurotoxins. The most important dinoflagellate toxins structures, their origin, structure and mechanisms of action were evaluated in a systematic review.
Materials & Methods: Marine dinoflagellates, marine toxins, and their mechanisms of action and structure were keywords for a comprehensive search in online databases including Pubmed, Science Direct, Google Scholar and Scirus. A total of 95 papers were evaluated, however, by omitting similar reports, 68 papers were included in the study.
Results: Dinoflagellates toxins are usually polycyclic ether and polyketaide compounds that have distinct mechanisms of action including alteration in different ion channels and/or pumps at cell membrane, effect on the normal functioning of neuronal and other excitable tissues, inhibition of serine/threonine phosphoprotein phosphatases, disrupting major mechanisms of controlling cellular functions, and alteration in cellular cytoskeleton. However, the precise mechanisms of action of few toxins are not determined yet.
Conclusion: The clarification of the dinoflagellate toxins structures and their mechanisms of action may be helpful for novel drug design, therapeutic measures and to overcome against marine toxicity.

 
Keyword(s): DINOFLAGELLATES, MARINE TOXINS, MARINE TOXICITY, MARINE TOXINOLOGY
 
 
References: 
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Click to Cite.
APA: Copy

NAJAFI, A., & NABIPOUR, I. (2016). THE STRUCTURE AND MODE OF ACTION OF THE DINOFLAGELLATE TOXINS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 19(3 ), 457-481. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569995



Vancouver: Copy

NAJAFI A., NABIPOUR I.. THE STRUCTURE AND MODE OF ACTION OF THE DINOFLAGELLATE TOXINS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ). 2016 [cited 2021May11];19(3 ):457-481. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569995



IEEE: Copy

NAJAFI, A., NABIPOUR, I., 2016. THE STRUCTURE AND MODE OF ACTION OF THE DINOFLAGELLATE TOXINS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), [online] 19(3 ), pp.457-481. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569995.



 
 
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